Integrative Structural Biology with Hybrid Methods

This book presentsa newemergingconcept of "Integrative Structural Biology". It coverscurrent trends of the molecular and cellular structural biology,providing new methods to observe, validate, and keep the structural models of the large cellular machines with recent scientific results. Structures of very large macromolecular machines in cells are being determined by combining observations from complementary experimental methods. Thus, this volume presents the each methods such as X-ray crystallography, NMR spectroscopy, 3DEM, small-angle scattering (SAS), FRET, crosslinking, and enables the readers to understandthe hybrid methods. This bookdiscusses how those integrative models should be represented, validated and archived. A unique highlight of this book is discussion ofthe data validation and archive, which are big problems in this filed along with the progress of this field. Theresearchersin biology will be interested inthis book as a guide book for learning the current structure biology, but also those instructure biologymay use this book as a comprehensive reference to cover broad topics.