This book constitutes the refereed proceedings of the19th International Conference on Information Systems Security, ICISS 2023, held in Raipur, India, during December 16–20, 2023. The 18 full papers and 10 short papers included in this book were carefully reviewed and selected from 78 submissions. They are organized in topical sections as follows: systems security, network security, security in AI/ML, privacy, cryptography, blockchains.