This book constitutes the refereed proceedings of the 19th International Conference on Information Security Practice and Experience, ISPEC 2024, held in Wuhan, China, during October 25–27, 2024. The 22 full papers presented in this volume were carefully reviewed and selected from 70 submissions. They cover multiple topics of cyber security and applied cryptography. The main goal of ISPEC 2024 conference was to promote research on new information security technologies, including their applications and their integration with IT systems in various vertical sectors.