"It gently but rigorously introduces most concepts used in statistical inference, with illustrative examples. It forms a useful reference for lecturers and for scientists/biostatisticians who are daily faced with tasks in biomedical data analysis."—Matthieu Vignes, PhD, Institute of Fundamental Sciences, Massey University in Australian & New Zealand Journal of Statistics"The first thing to like about it is the size! No weighty tome to fill students with dread. . . the practical issues of dealing with multiparameter models and elimination of nuisance parameters are well described and the calculation shown in detail."—Cono Ariti, International Society for Clinical Biostatistics"… covers not only the core theoretical foundations of the subject, but also many real-life applications and examples that the author drew from his extensive teaching and industry experience. … Simulations are designed to reinforce the repeated sampling interpretation and many R functions are made available for readers to have an easy hands-on experience. All these efforts allow the book to empower readers to develop their own thorough understanding of biostatistical methods."—Journal of Biopharmaceutical Statistics