Infections Causing Human Cancer

From 1983 until his retirement in 2003, Harald zur Hausen acted as chairman of the management board and scientific director of the German Cancer Research Center in Heidelberg until his retirement in. Previously he worked at a number of different universities in the USA and Germany. Professor zur Hausen has served on a large number of different scientific and policy bodies in many different countries including the European Board of Directors of HUGO, the International Scientific Advisory Committee of the French National Cancer Institute and Vice-Chairman of the German American Academic Council.In 2008 Professor zur Hausen was awarded the Nobel Prize in Physiology/Medicine for his research on the relationship between infections and cancer. Among his many other awards, he has held the Robert Koch Award, the Charles S. Mott Prize of the General Motors Cancer Research Foundation, the Paul Ehrlich and Ludwig Darmstaedter Award, the German Cancer Award, and the Federal Order of Merit, as well as six honorary degrees and seven visiting professorships.

• 1 Historical Review 11.1 The Early Period (1898–1911) 11.2 Frustration and Successes (1912–1950) 21.3 The Period from 1950 to 1965 31.4 A First Human Tumorvirus? 51.5 The Difficult 1970s 61.6 The Re-Emergence of a Concept 72 The Quest for Causality 172.1 Infectious Agents as Direct Carcinogens 202.2 Infectious Agents as Indirect Carcinogens 223 Tumors Linked to Infections: Some General Aspects 274 Herpesviruses and Oncogenesis 414.1 Alphaherpesvirinae 444.2 Betaherpesvirinae 514.3 Gammaherpesvirinae (Lymphocryptoviruses) 654.4 Rhadinoviruses 1185 Papillomavirus Infections: A Major Cause of Human Cancers 1455.1 Introduction 1455.2 The Concept of Cellular Interfering Cascades: Immunological, Intracellular and Paracrine Host Factors Influencing Viral Oncogene Expression or Function 1665.3 Cancers Linked to HPV Infections 1745.4 The Role of Cofactors 1885.5 Preventive Vaccination 1945.6 Therapeutic Vaccination 1955.7 Therapy 1976 Hepadnaviruses 2446.1 Hepatitis B 2447 Flaviviruses 2747.1 Hepatitis C Virus 2748 Retrovirus Family 3048.1 Human T-Lymphotropic Retrovirus (HTLV-1) 3068.2 Human T-Lymphotropic Retrovirus-2 (HTLV-2) 3378.3 Human Endogenous Retroviruses 3418.4 Gibbon Ape Leukemia Virus and Simian Sarcoma Virus 3619 Other Virus Infections Possibly Involved in Human Cancers 3669.1 Polyomaviruses (JC, BK, and SV40) 36610 Helicobacter, Chronic Inflammation, and Cancer 386James G. Fox, Timothy C. Wang, and Julie Parsonnet10.1 Discovery, Taxonomy, and Genomics 38610.2 Life Cycle, Specificity, and Virulence Determinants in Cancer Development 39610.3 Prevention of H. pylori-Induced Cancer 42410.4 Animal Models 42610.5 Virulence Determinants of Enterohepatic Helicobacter spp. 43710.6 Enterohepatic Helicobacter spp.: Are they Co-Carcinogens? 44011 Parasites and Human Cancers 46811.1 Schistosoma Infections 46811.2 Infection with Liver Flukes (Opisthorchis viverrini, O. felineus, Clonorchis sinensis) 47712 Cancers with a Possible Infectious Etiology 48512.1 Leukemias and Lymphomas 48512.2 Human Breast Cancer 50012.3 Other Human Cancers Possibly Linked to Infectious Events 502References 503

"You should consider purchasing it." (Lab Times)"This book will serve as a useful reference in understanding some of these infectious agents and their role in development of cancer." (The Yale Journal of Biology and Medicine, March 2008)"The causal relationship between infectious diseases and cancer is at the core of this engaging text...." (Journal of the American Medical Association, February 20, 2008)"This interesting collection of research and ideas should lead to some challenging discoveries, and hopefully, therapy to treat and prevent cancer." (Doody's Health Services)"... suitable as a teaching text in all advanced medicine courses that seek to explore the causal basis for cancer ... practicing scientists in the realm of oncology, microbiology and molecular biology will find zur Hausen's treatise applicable to advancing their own research." (Electric Review, February/March 2007)