Induced Pluripotent Stem Cells in Brain Diseases

Understanding the Methods, Epigenetic Basis, and Applications for Regenerative Medicine.

Häftad, Engelska, 2011

Av Vivi M. Heine, Stephanie Dooves, Dwayne Holmes, Judith Wagner

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This book discusses the various methods to reprogram cells, the control and determination of cell identity, the epigenetic models that have emerged and the application of iPS cell therapy for brain diseases, in particular Parkinson’s disease and Vanishing White Matter (VWM).?

Produktinformation

Utgivningsdatum2011-11-24
Mått155 x 235 x 6 mm
Vikt134 g
FormatHäftad
SpråkEngelska
SerieSpringerBriefs in Neuroscience
Antal sidor59
Upplaga2012
FörlagSpringer
ISBN9789400728158

Tillhör följande kategorier

Medicinsk genetik inom Medicin
Biologi inom Naturvetenskap och teknik
Biovetenskap inom Naturvetenskap och teknik
Pediatrik inom Medicin
Neurologi och klinisk neurofysiologi inom Medicin

Dr. Vivi M. Heine is an assistant professor in the Department of Pediatrics of the VU University Medical Center in Amsterdam, Netherlands. Dr. Heine earned her doctoral degree in Neurobiology from the University of Amsterdam, Netherlands. She then received post-doctoral training at the Dana Farber Cancer Institute, Harvard University, Boston and at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California at San Francisco. She obtained a tenure track position in 2010.

I. Introduction.- II. Cell Reprogramming: A New Era in Regenerative Medicine.- a. Stem Cells.- b. Reprogramming Methods.- c. Measuring Pluripotency, Efficiency, and Identity.- d. Induced Pluripotent Stem Cells versus Embryonic Stem Cells.- III. Understanding Epigenetic Memory is the Key to Successful Reprogramming.- a. Pre-fertilization to Embryo.- b. Epigenetic Control in De-, Re-, and Trans-differentiation.- IV. Prospects for Cell Replacement Therapies for Brain Diseases.- a. Parkinson’s Disease.- b. Childhood Brain White Matter Disorders.- V. Conclusions.- VI. Acknowledgement.- VII. References.