Shayne C. Gad, GAD Consulting Services, Raleigh, North Carolina

• Contributors; Preface 1. Introduction 2. General Principles for In Vitro 3. Ocular Toxicity Assessment In Vitro Toxicology 4. In Vitro Methods to Predict Skin Irritation 5. Lethality Testing 6. In Vitro Genetic Toxicity Testing 7. Pyrogenicity and Muscle Irritation 8. In Vitro Models for Evaluating Developmental Toxicity 9. Neurotoxicology In Vitro 10. In Vitro Assessment of Nephrotoxicity 11. Primary Hepatocyte Culture as an In Vitro Toxicologic System for the Liver 12. Application of In Vitro Model Systems to Study Cardiovascular Toxicity 13. Gastrointestinal Toxicology: In Vitro Test Systems 14. In Vitro Immonotoxicology 15. Strategy and Tactics for Employment 16. Scientific and Regulatory Considerations in the Development of In Vitro Techniques in Toxicology 17. Safety Issues in the Use of Human Tissue by In Vitro Metabolism and Toxicology Laboratories; Index

Shayne C. Gad, GAD Consulting Services, Raleigh, North Carolina

• Contributors; Preface 1. Introduction 2. General Principles for In Vitro 3. Ocular Toxicity Assessment In Vitro Toxicology 4. In Vitro Methods to Predict Skin Irritation 5. Lethality Testing 6. In Vitro Genetic Toxicity Testing 7. Pyrogenicity and Muscle Irritation 8. In Vitro Models for Evaluating Developmental Toxicity 9. Neurotoxicology In Vitro 10. In Vitro Assessment of Nephrotoxicity 11. Primary Hepatocyte Culture as an In Vitro Toxicologic System for the Liver 12. Application of In Vitro Model Systems to Study Cardiovascular Toxicity 13. Gastrointestinal Toxicology: In Vitro Test Systems 14. In Vitro Immonotoxicology 15. Strategy and Tactics for Employment 16. Scientific and Regulatory Considerations in the Development of In Vitro Techniques in Toxicology 17. Safety Issues in the Use of Human Tissue by In Vitro Metabolism and Toxicology Laboratories; Index

Shayne C. Gad, GAD Consulting Services, Raleigh, North Carolina

• Contributors; Preface 1. Introduction 2. General Principles for In Vitro 3. Ocular Toxicity Assessment In Vitro Toxicology 4. In Vitro Methods to Predict Skin Irritation 5. Lethality Testing 6. In Vitro Genetic Toxicity Testing 7. Pyrogenicity and Muscle Irritation 8. In Vitro Models for Evaluating Developmental Toxicity 9. Neurotoxicology In Vitro 10. In Vitro Assessment of Nephrotoxicity 11. Primary Hepatocyte Culture as an In Vitro Toxicologic System for the Liver 12. Application of In Vitro Model Systems to Study Cardiovascular Toxicity 13. Gastrointestinal Toxicology: In Vitro Test Systems 14. In Vitro Immonotoxicology 15. Strategy and Tactics for Employment 16. Scientific and Regulatory Considerations in the Development of In Vitro Techniques in Toxicology 17. Safety Issues in the Use of Human Tissue by In Vitro Metabolism and Toxicology Laboratories; Index