In Vitro Methods in Pharmaceutical Research

Inbunden, Engelska, 1996

Av Jose V. Castell, Maria Jose Gmez-Lechn, Spain) Castell, Jose V. (University Hospital 'La Fe', Valencia, Spain) Gmez-Lechn, Maria Jose (University Hospital 'La Fe', Valencia

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In Vitro Methods in Pharmaceutical Research provides a comprehensive guide to laboratory techniques for evaluating in vitro organ toxicity using cellular models. Step-by-step practical tips on how to perform and interpret assays for drug metabolism and toxicity assessment are provided, along with a comparison of different techniques available. It is a welcome addition to the literature at a time when interest is growing in cellular in vitro models for toxicology and pharmacology studies.

Meets the continuing demand for information in this field
Compares In Vitro techniques with other methods
Describes cell-culture methods used to investigate toxicity in cells derived from different organs
Includes contributions by leading experts in the field

Produktinformation

Utgivningsdatum1996-10-04
Mått142 x 229 x 0 mm
Vikt1 030 g
FormatInbunden
SpråkEngelska
Antal sidor467
FörlagElsevier Science
ISBN9780121633905

Tillhör följande kategorier

Tillverkningsteknik inom Naturvetenskap och teknik
Medicinsk utrustning och medicinska tekniker inom Medicin
Farmakologi inom Medicin

D.W. Straughan, J.H. Fentem, and M. Balls, Replacement Alternative and Complementary In Vitro Methods in Pharamaceutical Research.M.D. Barratt and M. Chamberlain, Integration of QSAR and In Vitro Toxicology.F.A. Barile, Continuous Cell Lines as a Model for Drug Toxicity Assessment.P. Bach, In Vitro Models for Nephrotoxicity Studies.A.E.M. Vickers, Experimental In Vitro Models to Evaluate Hepatotoxicity.M.J. Gomez-Lechon, T. Donato, X. Ponsoda, R. Fabra, R. Trullenque, and J.V. Castell, Isolation, Culture and Use of Human Hepatocytes in Drug Research.E. McFarlane-Abdulla, and I.C. Campbell, Studies of Nephrotoxicity in Cellular Studies.M. Adolphe, S. Thenet-Gauci, and S. Demignot, Chondrocyte Culture: A Target System to Evaluate Pharmaco-Toxicological Effects of Drugs.E. Chacon, D. Acosta, and J.J. Lemasters, Primary Cultures of Cardiac Myocytes as In Vitro Models for Pharmacological andToxicological Assessments.R. Roguet, Cutaneous Pharmacotoxicology In Vitro.H. Spielmann, Ocular Irritation.M.A. Miranda, Phototoxicity of Drugs.I. de G. Mitchell and R.D. Combes, In Vitro Genotoxicity and Cell Transformation Assessment.B. Schmid, R. Bechter, and P. Kucera, The Use of Whole Embryo Cultures in In Vitro Teratogenicity Testing.J.V. Castell, M.J. Gomez-Lechon, X. Ponsoda, and R. Bort, In Vitro Investigation of the Molecular Mechanisms of Hepatotoxicity.A. Guillouzo, Biotransformation of Drugs by Hepatocytes.K. Mace, E.A. Offord, and A.M.A. Pfeifer, Drug Metabolism and Carcinogen Activation Studies with Human Genetically Engineered Cells.