Importance of Animal Experimentation for Safety and Biomedical Research

• The necessity of animal experimentation.- Ethical and Legal Aspects.- Animal experimentation defended.- The ethics of animal use in biomedicine.- Legal and political problems of animal experimentation, the ‘Swiss battle’.- Experimentation and the law.- Experimentation on animals: animals as machines and animals as fetishes.- Recent Progress of Medicine Requiring the Use of Animals.- The role of animal experiments in pharmacological brain research.- Regeneration of the nervous system.- Endocrine glands, neuroendocrinology and animal experimentation.- Laboratory animals and cardiovascular pathology: means for better use.- The importance of animal models for hypertension research.- Animal experiments and recent progress in thrombosis research.- Models of human renal disease.- The necessity of animal experimentation in tumor immunology.- The use of animals in cancer chemotherapy.- The use of experimental animals in transplantation research.- Animal models for AIDS research.- The need for animal experimentation in drug and vaccine development against tropical diseases.- Use of Animals for Safety Reasons.- Toxicology: role of in vivo studies in establishing mcchanisms of toxicity.- Necessity of animal experiments for the safety evaluation and necessary consequences for public health.- The necessity of animal testing for safety evaluation and medical progress in reproductive biology and toxicology.- The need for animal experimentation in studying the carcinogenic risk of substances.- The Future of Animal Research.- Transgenic animals for human diseases and gene therapy.- Recent progress toward reducing the use of animal experimentation in biomedical research.- Animal use in drug research.

'This book should be read by all medical scientists and practising doctors, and also by any intelligent layman who wishes to be informed on an increasingly contentious issue. The book is properly and nicely printed ...' Adverse Drug Reactions, 9/3, 1990