M. Molls, Professor, Chairman of the Department of Radiation Oncology, Klinikum rechts der Isar der TU Muenchen, Germany C. Nieder, Professor at the University of Tromso, Norway, Oncologist M Anscher, Professor and Chairman, Department of Radiation Oncology, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA

• Tumorigenesis.- Tumor Growth and Cell Proliferation.- Tumor Angiogenesis.- Pathophysiology of Solid Tumors.- Adhesion, Invasion, Integrins, and Beyond.- The Biology of Cancer Metastasis.- Role of the Immune System in Cancer Development and Therapeutic Implications.- Tumor Detection by Biological Markers.- Tumor Imaging with Special Emphasis on the Role of Positron Emission Tomography in Radiation Treatment Planning.- Quantitative Cell Kill of Radio- and Chemotherapy.- The Impact of Molecularly Targeted Therapy in Multi-Modality Therapy.- Target-Based Interventions to Treat Radiation-Induced Lung Injury.- Mechanisms of Treatment Resistance: Molecular and Clinical Examples for Radio- and Chemotherapy.- DNA Repair and Cell Cycle Regulation After Ionizing Irradiation.- Physiological Mechanisms of Treatment Resistance.- Influence of Time Factor and Repopulation on Treatment Resistance.- Molecular Tools, Expression Profiling.- Strategies of Gene Transfer and Silencing, and Technical Considerations.- Tumor Biology’s Impact on Clinical Cure Rates.- Dose-Escalated High-Precision Radiotherapy: a Method to Overcome Variations in Biology and Radiosensitivity Limiting the Success of Conventional Approaches?.- Treatment of the Primary Tumor in Metastatic Cancer: Influence on Outcome.

From the reviews: "The stated aim of the editors of this book is 'to provide the practising radiation oncologist with a concise overview of the most important and up-to-date information pertaining to tumour biology as it impacts on cancer treatment' ... useful guide to the molecular era of cancer biology and personalised cancer therapy, particularly in relation to radiation oncology. ... The book would be of interest to any oncologist and would serve as a useful revision tool for the FRCR part 1 examination." (Joe O'Sullivan, RAD Magazine, December, 2009) Aus den Rezensionen: "Dieses umfassende Lehrbuch erlautert alle wesentlichen Gesichtspunkte der Tumorbiologie ... Die Literaturhinweise sind umfangreich, vollstandig und aktuell, sofern dies in einem Lehrbuch uberhaupt moglich ist. Die Autoren sind international ausgewiesene Grundlagenwissenschaftler und klinische Krebsforscher. Die Kapitel weisen ein qualitativ hochwertiges Layout mit zahlreichen, durchgehend farbigen Bildern auf und sind gut lesbar. Das Buch stellt eine wesentliche Bereicherung der tumorbiologischen Literatur dar. Wir empfehlen es als aktuelles radiobiologisches Standardwerk." (Stephan Roth, in: Strahlentherapie und Onkologie, 1/December/2009, S. 844)

M. Molls, Professor, Chairman of the Department of Radiation Oncology, Klinikum rechts der Isar der TU Muenchen, Germany C. Nieder, Professor at the University of Tromso, Norway, Oncologist M Anscher, Professor and Chairman, Department of Radiation Oncology, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA

• Tumorigenesis.- Tumor Growth and Cell Proliferation.- Tumor Angiogenesis.- Pathophysiology of Solid Tumors.- Adhesion, Invasion, Integrins, and Beyond.- The Biology of Cancer Metastasis.- Role of the Immune System in Cancer Development and Therapeutic Implications.- Tumor Detection by Biological Markers.- Tumor Imaging with Special Emphasis on the Role of Positron Emission Tomography in Radiation Treatment Planning.- Quantitative Cell Kill of Radio- and Chemotherapy.- The Impact of Molecularly Targeted Therapy in Multi-Modality Therapy.- Target-Based Interventions to Treat Radiation-Induced Lung Injury.- Mechanisms of Treatment Resistance: Molecular and Clinical Examples for Radio- and Chemotherapy.- DNA Repair and Cell Cycle Regulation After Ionizing Irradiation.- Physiological Mechanisms of Treatment Resistance.- Influence of Time Factor and Repopulation on Treatment Resistance.- Molecular Tools, Expression Profiling.- Strategies of Gene Transfer and Silencing, and Technical Considerations.- Tumor Biology’s Impact on Clinical Cure Rates.- Dose-Escalated High-Precision Radiotherapy: a Method to Overcome Variations in Biology and Radiosensitivity Limiting the Success of Conventional Approaches?.- Treatment of the Primary Tumor in Metastatic Cancer: Influence on Outcome.

From the reviews: "The stated aim of the editors of this book is 'to provide the practising radiation oncologist with a concise overview of the most important and up-to-date information pertaining to tumour biology as it impacts on cancer treatment' ... useful guide to the molecular era of cancer biology and personalised cancer therapy, particularly in relation to radiation oncology. ... The book would be of interest to any oncologist and would serve as a useful revision tool for the FRCR part 1 examination." (Joe O'Sullivan, RAD Magazine, December, 2009) Aus den Rezensionen: "Dieses umfassende Lehrbuch erlautert alle wesentlichen Gesichtspunkte der Tumorbiologie ... Die Literaturhinweise sind umfangreich, vollstandig und aktuell, sofern dies in einem Lehrbuch uberhaupt moglich ist. Die Autoren sind international ausgewiesene Grundlagenwissenschaftler und klinische Krebsforscher. Die Kapitel weisen ein qualitativ hochwertiges Layout mit zahlreichen, durchgehend farbigen Bildern auf und sind gut lesbar. Das Buch stellt eine wesentliche Bereicherung der tumorbiologischen Literatur dar. Wir empfehlen es als aktuelles radiobiologisches Standardwerk." (Stephan Roth, in: Strahlentherapie und Onkologie, 1/December/2009, S. 844)

M. Molls, Professor, Chairman of the Department of Radiation Oncology, Klinikum rechts der Isar der TU Muenchen, Germany C. Nieder, Professor at the University of Tromso, Norway, Oncologist M Anscher, Professor and Chairman, Department of Radiation Oncology, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA

• Tumorigenesis.- Tumor Growth and Cell Proliferation.- Tumor Angiogenesis.- Pathophysiology of Solid Tumors.- Adhesion, Invasion, Integrins, and Beyond.- The Biology of Cancer Metastasis.- Role of the Immune System in Cancer Development and Therapeutic Implications.- Tumor Detection by Biological Markers.- Tumor Imaging with Special Emphasis on the Role of Positron Emission Tomography in Radiation Treatment Planning.- Quantitative Cell Kill of Radio- and Chemotherapy.- The Impact of Molecularly Targeted Therapy in Multi-Modality Therapy.- Target-Based Interventions to Treat Radiation-Induced Lung Injury.- Mechanisms of Treatment Resistance: Molecular and Clinical Examples for Radio- and Chemotherapy.- DNA Repair and Cell Cycle Regulation After Ionizing Irradiation.- Physiological Mechanisms of Treatment Resistance.- Influence of Time Factor and Repopulation on Treatment Resistance.- Molecular Tools, Expression Profiling.- Strategies of Gene Transfer and Silencing, and Technical Considerations.- Tumor Biology’s Impact on Clinical Cure Rates.- Dose-Escalated High-Precision Radiotherapy: a Method to Overcome Variations in Biology and Radiosensitivity Limiting the Success of Conventional Approaches?.- Treatment of the Primary Tumor in Metastatic Cancer: Influence on Outcome.

From the reviews: "The stated aim of the editors of this book is 'to provide the practising radiation oncologist with a concise overview of the most important and up-to-date information pertaining to tumour biology as it impacts on cancer treatment' ... useful guide to the molecular era of cancer biology and personalised cancer therapy, particularly in relation to radiation oncology. ... The book would be of interest to any oncologist and would serve as a useful revision tool for the FRCR part 1 examination." (Joe O'Sullivan, RAD Magazine, December, 2009) Aus den Rezensionen: "Dieses umfassende Lehrbuch erlautert alle wesentlichen Gesichtspunkte der Tumorbiologie ... Die Literaturhinweise sind umfangreich, vollstandig und aktuell, sofern dies in einem Lehrbuch uberhaupt moglich ist. Die Autoren sind international ausgewiesene Grundlagenwissenschaftler und klinische Krebsforscher. Die Kapitel weisen ein qualitativ hochwertiges Layout mit zahlreichen, durchgehend farbigen Bildern auf und sind gut lesbar. Das Buch stellt eine wesentliche Bereicherung der tumorbiologischen Literatur dar. Wir empfehlen es als aktuelles radiobiologisches Standardwerk." (Stephan Roth, in: Strahlentherapie und Onkologie, 1/December/2009, S. 844)