Bruce Kaplan, MD, Professor of Medicine, Surgery and Pharmacology, Co-Director UIC Transplant Center, University of Illinois at Chicago, USA and Adjunct Professor of Medicine, Applied Genomics Center, University of Alberta, Canada. Gilbert Burkhart, Pharm D, Department of Medicine, University of Southern California (USC), San Francisco, USA. Phil Halloran, MD, PhD, Professor of Medicine, Director of Nephrology and Immunology, University of Alberta, Edmonton, Canada.

• List of Contributors, viiPreface, xiPart 1 Transplantation Immunobiology1 The Immune Response to a Transplanted Organ: An Overview, 3Fadi G. Lakkis2 Antigen Presentation in Transplantation, 10Martin H. Oberbarnscheidt and Fadi G. Lakkis3 The T Cell Response to Transplantation Antigens, 19Didier A. Mandelbrot, Bryna Burrell, Mohamed H. Sayegh, and Peter S. Heeger4 The B Cell Response to Transplantation Antigens, 38Roger Sciammas, Anita S. Chong, and Robert B. Colvin5 The Innate Response to a Transplanted Organ, 54Daniel R. Goldstein and Laurence A. Turka6 Regulation of the Alloimmune Response, 62Kathryn J. Wood and Terry B. StromPart 2 Transplantation Clinical Pharmacology7 Pharmacokinetics, 81Venkateswaran C. Pillai and Raman Venkataramanan8 Therapeutic Drug Monitoring for Immunosuppressive Agents, 95Michael C. Milone and Leslie M.J. Shaw9 Pharmacometrics: Concepts and Applications to Drug Development, 114Mallika Lala and Jogarao V.S. Gobburu10 Pharmacogenomics and Organ Transplantation, 133Gilbert J. Burckart and Richard M. Watanabe11 Study Design/Process of Development: Clinical Studies, 146Richard D. MamelokPart 3 Agents12 Corticosteroids, 163Olivia R. Blume, Sarah E. Yost, and Bruce Kaplan13 Azathioprine, 171Barry J. Brown14 Pharmacokinetic and Pharmacodynamic Properties of Mycophenolate, 182David Hager, Arjang Djamali, and Bruce Kaplan15 Cyclosporine: Molecular Action to Clinical Therapeutics, 197Bradford Strijack and Paul A. Keown16 Tacrolimus, 224William E. Fitzsimmons17 Inhibitors of Mammalian Target of Rapamycin, 241Barry D. Kahan18 Inhibitors Targeting JAK3, 273Gary Chan and Paul S. Changelian19 Cyclophosphamide, 290John J. Curtis20 Application of Antisense Technology in Medicine, 296Beata Mierzejewska and Stanislaw M. Stepkowski21 The Role of Ganciclovir in Transplantation, 316Lyndsey J. Bowman and Daniel C. Brennan22 Transplantation Immunotherapy with Antithymocyte Globulin (ATG), 330John L. Dzuris, Christian Bloy, Melanie Ruzek, and John M. Williams23 The Role of Alemtuzumab in Solid Organ Transplantation, 346Avinash Agarwal, David Bruno, and Stuart J. Knechtle24 Rituximab, an Anti-CD20 Monoclonal Antibody, 362Mark D. Pescovitz25 The Anti-Interleukin 2 Receptor Antibodies, 378Muna Alnimri and Flavio Vincenti26 Infliximab/Anti-TNF, 385Marina Vardanyan, Edward C. Parkin, and Horacio L. Rodriguez Rilo27 CTLA4-Ig, 399Sarah E. Yost and Bruce Kaplan28 Combination and Adjuvant Therapies to Facilitate the Efficacy of Costimulatory Blockade, 407Swetha K. Srinivasan, Helen L. Triemer, and Allan D. Kirk29 Intravenous Immunoglobulin (IVIG) a Modulator of Immunity and Inflammation with Applications in Solid Organ Transplantation, 429Stanley C. Jordan, Mieko Toyoda, Joseph Kahwaji, Alice Peng, and Ashley A. VoIndex, 447Color plates are found facing p. 213

“Overall, the text is highly structured, well presented and applicable to transplant clinicians and pharmacologists in particular. . . . Those wishing to advance their understanding of transplant immunology, the technologies and techniques used for drug monitoring, the drug development pipeline and the basis for use of current agents in transplantation will find their interests more than satisfied.”  (American Journal of Transplantation, 5 September 2013)“It will serve a clinician well as a focused reference for immunology and pharmacotherapy relevant to the transplant arena. It would be a welcome and useful addition to the medical or pharmaceutical library of a transplant professional or institution, albeit on the expensive side for a focused textbook.”  (The Annals of Pharmacotherapy, 1 March 2013)“This comprehensive reference source will benefit all transplant specialists working with pharmacologic and biologic agents that modulate the immune system.”  (European Journal of Immunology, 1 December 2012)“This is a decent review of transplant immunology that is helpful for the training practitioner. Given its systematic approach, it is easier to follow than other books on the subject.”  (Doody’s, 17 August 2012)