Immunotherapy in Translational Cancer Research

Inbunden, Engelska, 2018

AvLaurence J. N. Cooper,Elizabeth A. Mittendorf,Judy Moyes,Sabitha Prabhakaran,USA) Cooper, Laurence J. N. (Associate Professor, Pediatrics, University of Texas MD Anderson Cancer Center, Houston, TX,USA) Mittendorf, Elizabeth A. (Professor, Department of Breast Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX,USA) Moyes, Judy (Department of Pediatric Research, The University of Texas MD Anderson Cancer Center, Houston, TX,USA) Prabhakaran, Sabitha (Clinical Research Scientist, Department of Breast Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX,Laurence J N Cooper,Elizabeth A Mittendorf

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A guide to state-of-the-art cancer immunotherapy in translational cancer research A volume in the Translational Oncology series, Immunotherapy in Translational Cancer Research explores the recent developments in the role that immunotherapy plays in the treatment of a wide range of cancers. The editors present key concepts, illustrative examples, and suggest alternative strategies in order to achieve individualized targeted therapy. Comprehensive in scope, Immunotherapy in Translational Cancer Research reviews the relevant history, current state, and the future of burgeoning cancer-fighting therapies. The book also includes critical information on drug development, clinical trials, and governmental resources and regulatory issues.Each chapter is created to feature: development of the immunotherapy; challenges that have been overcome in order to scale up and undertake clinical trials; and clinical experience and application of research. This authoritative volume is edited by a team of noted experts from MD Anderson Cancer Center, the world’s foremost cancer research and care center and: Offers a comprehensive presentation of state-of-the-art cancer immunotherapy research that accelerates the pace of clinical cancer care Filled with the concepts, examples, and approaches for developing individualized therapyExplores the breath of treatments that reflect the complexity of the immune system itselfIncludes contributions from a panel international experts in the field of immunotherapyDesigned for physicians, medical students, scientists, pharmaceutical executives, public health and public policy government leaders and community oncologists, this essential resource offers a guide to the bidirectional interaction between laboratory and clinic immunotherapy cancer research.

Produktinformation

Utgivningsdatum2018-04-18
Mått183 x 257 x 18 mm
Vikt816 g
FormatInbunden
SpråkEngelska
SerieTranslational Oncology
Antal sidor312
FörlagJohn Wiley and Sons Ltd
ISBN9781118123225

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Onkologi inom Medicin

Laurence J. N. Cooper, Associate Professor, Department of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, USA. Elizabeth A. Mittendorf, Professor, Department of Breast Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA. Judy Moyes, Department of Pediatric Research, The University of Texas MD Anderson Cancer Center, Houston, USA. Sabitha Prabhakaran, Clinical Research Scientist, Department of Breast Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA.

Editors viContributors viiIntroduction ix1 Translation in Immunology: The Role of Translational Biomarkers to Guide Clinical Use of Immunotherapy for Cancer 1Saranya Chumsri and Keith L. Knutson2 Monoclonal Antibody Therapy 12Elizabeth A. Mittendorf and Sabitha Prabhakaran3 Somatic Mutations and Immunotherapy 24Eric Tran4 Checkpoint Blockade 37Tracy A. Proverbs‐Singh Jedd Wolchok and Alexandra Snyder5 Myeloid Leukemia Vaccines 54Paul M. Armistead and Jonathan S. Serody6 Cancer Vaccines for Solid Tumors 72Timothy J. Vreeland Garth S. Herbert and George E. Peoples7 Immunotherapy with Non–Genetically Modified T Cells 91Cassian Yee8 Immunotherapy with Genetically Modified T Cells 101Liora Schultz and Crystal Mackall9 Immunomodulation with Adjuvants and Cytokines 115Dae won Kim and Adi Diab10 Immune Cell Migration in Cancer and Immunotherapy 132Timothy Murray and Daniel E. Speiser11 Repurposing of Drugs for Immunotherapy 143Jyothishmathi Swaminathan and Vidya Gopalakrishnan12 Immunomodulation with Radiation 161Jonathan E. Schoenhals Taylor R. Cushman, Alexandra P. Cadena Sandra Demaria and James W. Welsh13 Good Manufacturing Practices Facilities for Cellular Therapy 177Andrew D. Fesnak and Bruce L. Levine14 T Cell Receptor Mimic Antibodies 186Gheath Alatrash and Jeffrey J. Molldrem15 Stem Cell Transplantation for Treatment of Malignancy 201Lohith S. Bachegowda and Richard E. Champlin16 Natural Killer Cell–Based Immunotherapy 215Jennifer A. Foltz Jeffrey S. Miller and Dean A. Lee17 Immunologic Monitoring in Immuno‐Oncology 228William R. Gwin and Mary L. Disis18 Cell‐Based Therapies for Canine Cancer 252Nicola J. Mason and M. Kazim Panjwani19 Interaction between Targeted Therapy and Immunotherapy 268Peter A. Prieto Miles C. Andrews, Alexandria P. Cogdill, and Jennifer A. WargoIndex 286