Immunoregulation in Inflammatory Bowel Diseases - Current Understanding and Innovation

• Advances in the pathogenesis of inflammatory bowel disease.- Innate immune responses in inflammatory bowel disease.- The adaptive immune responses in inflammatory bowel disease.- Relevance of bacteria in the pathogenesis of inflammatory bowel disease.- Taking a toll on MD-2 in inflammatory bowel disease.- Optimization in therapy through improved disease classification?.- Classification of inflammatory bowel disease can only be based on the clinical phenotype.- Use of serology and genetics to differentiate inflammatory bowel disease phenotypes.- Do biomarkers help to optimize therapy in inflammatory bowel disease?.- Role of pharmacogenetics in the management of inflammatory bowel diseases.- Conventional immunomodulator therapy.- State-of-the-art therapy in accordance with guidelines.- Increased risk of morbidity associated with immunomodulatory treatment in patients with inflammatory bowel diseases.- Can immunomodulatory therapy be improved by metabolite measurement and combination therapy?.- Relevance of biologics.- Top-down therapy for inflammatory bowel disease.- ’step-up’ versus ‘top-down’ strategies in inflammatory bowel disease — what do we know in 2006?.- Importance of mucosal healing in Crohn’s disease and ulcerative colitis.- State-of-the-Art Lecture: Distinct antibacterial-defensin deficiencies in small intestinal and colonic Crohn’s disease.- New therapeutic approaches (Part I).- Oligonucleotides — new therapeutic approaches.- Probiotics in inflammatory bowel disease.- Helminth ova therapy for inflammatory bowel disease.- Retarded release phosphatidylcholine: a new therapeutic option for ulcerative colitis.- Topical steroids — rectal application.- New therapeutic approaches (Part II).- Apheresis.- The evolving understanding and therapy ofCrohn’s disease: innate immunity and sargramostim (GM-CSF).- Immunosuppression with tacrolimus, everolimus and sirolimus.- T-cell modulating antibodies in inflammatory bowel disease.

From the reviews: "This book ... reviews established and emerging concepts in the diagnosis and treatment of IBD and reflects the recent advances in knowledge about the pathophysiology of Crohn's disease and ulcerative colitis. ... the book is 'essential reading' aimed at 'both basic scientist and clinicians'." (Willem JS de Villiers, Doody's Review Service, March, 2009)