Warren Strober, M.D., is Section Chief in the Laboratory of Clinical Investigation, Mucosal Immunity Section at the National Institute of Allergy and Infectious Diseases, National Institutes of Health. Susan R.S. Gottesman, M.D., Ph.D., is Associate Professor in the Department of Pathology at SUNY Health Science Center at Brooklyn.

• Preface, ixContributors, xiIndex of Lessons in Normal Immunity, xiiiINTRODUCTION TO CASE STUDIES: A GUIDE TO USING THIS BOOK, 1Unit I IMMUNODEFICIENCY DISEASES, 3INTRODUCTION: ORGANIZATION OF THE IMMUNE SYSTEM AND EVALUATION OF THE IMMUNODEFICIENT PATIENT, 51 X-LINKED AGAMMAGLOBULINEMIA (BRUTON’S AGAMMAGLOBULINEMIA), 152 SEVERE COMBINED IMMUNODEFICIENCY DISEASE, 273 DiGEORGE SYNDROME (CONGENITAL THYMIC APLASIA), 414 HYPER-IgM SYNDROME, 535 COMMON VARIABLE IMMUNODEFICIENCY DISEASE, 676 AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROME (ALPS), 817 X-LINKED LYMPHOPROLIFERATIVE SYNDROME, 918 HEREDITARY ANGIOEDEMA, 1019 ACQUIRED IMMUNODEFICIENCY SYNDROME, 111Unit II IMMEDIATE HYPERSENSITIVITY AND MAST CELL DISORDERS, 125INTRODUCTION: WHEN ANTIGENS BECOME ALLERGENS, 12710 MASTOCYTOSIS, 12911 ANAPHYLAXIS, 13712 ASTHMA, 14713 THE VASCULITIDES, 161Unit III AUTOIMMUNE DISORDERS, 173INTRODUCTION: OVERVIEW OF AUTOIMMUNE DISORDERS AND MECHANISMS OF TOLERANCE, 17514 MYASTHENIA GRAVIS, 18315 MULTIPLE SCLEROSIS, 19516 DIABETES MELLITUS TYPE 1, 20717 CELIAC DISEASE, 21918 INFLAMMATORY BOWEL DISEASE, 23119 PSORIASIS, 24520 IgA NEPHROPATHY AND KIDNEY TRANSPLANTATION, 25521 RHEUMATOID ARTHRITIS, 26922 SYSTEMIC LUPUS ERYTHEMATOSUS, 28323 SCLERODERMA, 299Unit IV MALIGNANCIES OF THE LYMPHOID SYSTEM, 309INTRODUCTION: CLASSIFICATION OF LYMPHOID MALIGNANCIES, 31124 CHRONIC LYMPHOCYTIC LEUKEMIA/SMALL LYMPHOCYTIC LYMPHOMA, 31725 FOLLICULAR LYMPHOMA, 32726 PLASMA CELL NEOPLASMS, 337Unit V 349LABORATORY TESTS USED IN THE WORKUP OF PATIENTS WITH IMMUNOLOGIC DISEASES, 351Index, 369

"In all, while written as a clinically-relevant companion for an immunology text, this book can stand alone as a wonderful resource for any clinical immunologist and can serve as an excellent teaching aid for anyone studying immunology or training in a field that cares for patients with immune disorders." (The World Allergy Organization, 1 August 2011)"[This book] effectively accomplishes its stated goals. This well-written and easy-to-read book covers a wide variety of topics... and provides a wealth of experience in a patient-oriented format. The editors of this book succeed in moving readers from beginning to end using this case-based approach. [This book] offers a number of teaching possibilities and could be useful in teaching immunology when combined with current textbooks." (JAMA, April 2010)