Immunology, Inflammation and Diseases of the Eye

In addition to his role as Senior Scientist and Co-Director at the Schepens Eye Research Institute, Dr. Reza Dana holds the Claes H. Dohlman Chair in Ophthalmology at Harvard Medical School. He is Director of the Cornea & Refractive Surgery Service at the Massachusetts Eye & Ear, and serves as the Vice Chairman of the Harvard Department of Ophthalmology and Associate Chief of Ophthalmology for Academic Programs at Massachusetts Eye and Ear. After graduating Summa Cum Laude from St. Paul’s School in New Hampshire, he completed his bachelor’s (Phi Beta Kappa), graduate, and medical education at Johns Hopkins University. He performed his residency in Ophthalmology at the Illinois Eye and Ear Infirmary in Chicago, followed by a clinical fellowship in Cornea and External Diseases at the Wills Eye Hospital in Philadelphia. Reza then completed additional fellowship training in Immunology and Uveitis at the Massachusetts Eye and Ear Infirmary, and in Ocular and Transplantation Immunology at the Schepens Eye Research Institute. Dr. Dana also holds a Master of Science degree in Management from Harvard University. Reza has been a member of the full-time Harvard faculty since 1995. As a clinician-scientist, he has a particular interest in the molecular and cellular mechanisms of inflammation as they pertain to the ocular surface and anterior segment pathologies, including dry eye, allergy, wound healing responses, and transplant rejection. Dr. D’Amore earned her PhD in Biology from Boston University, was a postdoctoral fellow in Biological Chemistry and Ophthalmology at Johns Hopkins Medical School, then moved to Boston Children’s Hospital as Assistant Professor where she remains Research Associate in Surgery. In 1998, she became Charles L. Schepens Professor of Ophthalmology and Professor of Pathology at Harvard Medical School and a Senior Scientist at Mass. Eye and Ear. She is the Associate Chief of Basic and Translational Research for Ophthalmology at Mass. Eye and Ear and the Vice Chair of Basic and Translational Research for the Department of Ophthalmology. Dr. D’Amore is an international expert in vascular growth and development and has been at the forefront of angiogenesis research for over three decades. She has published more than 170 peer-reviewed papers, 75 reviews, and edited or co-edited two books.

• I. Regulation of the Immune Response of the Eye and Its Dysregulation in Inflammation and InfectionAdaptive Immune System and the Eye: Mucosal ImmunityAdaptive immune system and the eye: T-cell mediated immunityInnate immune system and the eyeDefense mechanisms of tears and ocular surfaceRole of complement in the ocular immune responseImmunoregulatory processes that sustain immune privilege in the eyeImmunosupressive and anti-inflammatory molecules that maintain immune previlege of the eyeAntigen-presenting cells in the eye and ocular surfaceRegenfus and Cursiefen- Angiogenesis in the eyeDry eye: An immune-based inflammationPenetrating keratoplastyCorneal epithelium- response to infectionImmunopathogenesis of HSV KeratitisImmunopathogenesis of Onchocerciasis (River Blindness)Immunopathogenesis of pseudomonas keratitisImmunobiology of acanthomeba karatitisPathogenesis of fungal keratitisMolecular and cellular mechanisms in allergic conjunctivitisConjunctiva Immune surveillanceInflammation of the ConjunctivaImmunopathogenesis of experimental uveitic diseasesPathogenesis of Uveitis in humansImmunobiology of uveal melanomaImmunobiology of age-related macular degenerationPathogenesis and Immunology of Bacterial endophthalmitisII. Angiogenesis in the Eye and Its Dysfunction in the Retina, Cornea and VitreousOrbiatl vascular anatomy Developmental anatomy of retinal and choroidal vasculatureDevelopment of the retinal vasculaturePhysiological Anatomy of the retinal vasculaturePhysiological anatomy of the choroidal vasculatureProperties and functions of the vessels of the ciliary bodyAnatomy and regulation of the optic nerve blood flowAngiogenesis in response to hypoxiaAngiogenesis and inflammationAngiogenesis in wound healingHemangiogenesis versus lymphangiogenesisInnate immunity and angiogenesisMechanisms of AngiostasisStability and functional integrity of new blood vesselsVessel regressionBlood-retinal barrierBreakdown of the blood-retinal barrierRetinal pigment epithelium barrierBreakdown of the retinal pigement epithelium blood-retinal barrierRetinal pigment epithelial-choroid interactionsMacular edemaCentral vein occlusionPathological retinal angiogenesisProliferative vitreoretinopathyChoroidal neovascularizationThe vascular stem cellConcept of Angiogenic PrivilegeCorneal angiogenesisAvascularity of the corneaAnti-angiogenic properties of vitreous