Dr. Satoshi KokuraKOKURA Lab, Health and MedicalSciences, Kyoto Gakuen UniversityKyoto, JapanDr. Toshikazu YoshikawaPresidentKyoto Prefectural University ofMedicineKyoto, Japan Dr. Takeo OhnishiDepartment of Radiation OncologyNara Medical UniversityNara, Japan

• Part I. Basic Science in Cultured Cells.- 1. Introduction.- 2.Induction of oxidative stress by hyperthermia and enhancement of hyperthermia-induced apoptosis by oxidative stress modification.- 3.Molecular Damage: Hyperthermia Alone.- 4.Roles of HSF1 and Heat Shock Proteins in Cancer.- 5.Cellular Responses in Signal Transduction Pathways Induced by Hyperthermia.- 6.Cell cycle responses to hyperthermia.- 7.Thermo-tolerance.- 8.Enhancement of Hyperthermia on Radio-sensitivity.- 9.Inhibition of DNA repair system activity.- 10. Enhancement of Hyperthermia on Anti-tumor Drug Sensitivity.- 11. Inhibition of epithelial-to-mesenchymal transition (EMT) by hyperthermia.- Part II. Basic Science in Whole Body.- 12.Potentiating Immune System by Hyperthermia.- 13. Magnetic Nanoparticle-Mediated Hyperthermia and Induction of Anti-Tumor Immune Responses.- 14. Tumor Microenvironment and Hyperthermia Part III. Clinical Science inCancer Patients..- 15. Hyperthermia Alone.- 16.Combination by Hyperthermia and Radiation (and Chemotherapy): Oral and Maxillofacial Cancer.- 17.Combination by Hyperthermia and Radiation (and Chemotherapy): Lung Cancer.- 18.Efficacy of hyperthermia in combination with radiation therapy for breast cancer.- 19.Combination by Hyperthermia and Radiation: Esophageal Cancer.- 20.Combination by Hyperthermia and Radiation (and Chemotherapy): Gynecology Cancer.- 21.Combination by Hyperthermia and Radiation and Chemotherapy: Soft Tissue Sarcoma.- 22.Combination by Hyperthermia and Chemotherapy: Lung Cancer.- 23. Combination by Hyperthermia and Chemotherapy: Breast Cancer.- 24.Combination by Hyperthermia and Chemotherapy: Esophageal Cancer.- 25.Combination by Hyperthermia and Chemotherapy: Liver Cancer.- 26.Hyperthermia Combined with Chemotherapy: Pancreatic Cancer.- 27.Effect of hyperthermia in combination with chemotherapy and radiation therapy for treatment of urological cancer (prostate cancer and urothelial cancer).- 28.Combination by Hyperthermia and Surgery.- 29.Combining Hyperthermia and Immunotherapy: NK Therapy and Hyperthermia.- 30.Combination by Hyperthermia and Immunotherapy: DC Therapy and Hyperthermia.- 31.Effects of fever-range hyperthermia on T cell-mediated immunity: possible combination of hyperthermia and T cell-based cancer immunotherapy.- 32.Combination of Hyperthermia and Immunotherapy: Hyperthermia and Naive T-cell Therapy.- 33.HIPEC for Peritoneal Dissemination.- 34.A new comprehensive treatment for peritoneal metastases using cytoreductive surgery combined with hyperthermic intraperitoneal  chemoperfusion.- 35.Non-invasive Temperature Moniterring.- 36.Development of Heating Device.- 37. Epilogue.