Hyaluronan Signaling and Turnover

Paraskevi Heldin, Ph.D., received her B.Sci. exam (Chemistry/Biochemistry Mathematics), Uppsala University in 1979 and her Ph.D., in Medical and Physiological Chemistry for studies on regulatory phosphorylation of proteins, Faculty of Medicine, Uppsala University, in 1987. After dissertation she changed research area and focused on the biology of hyaluronan under the supervision of Professor T.C. Laurent, Uppsala University. She worked at Department of Medical and Physiological Chemistry during 1987- 2000, and was awarded Docent appointment in Medical and Physiological Chemistry and Scientist Position from The Göran Gustafsson Foundation. Since 2001, she is Adjunct Associate Professor at the Department of Medical Biochemistry and Microbiology, and Associate Investigator and Head of the Matrix Biology Group in Ludwig Institute for Cancer Research, Uppsala, Sweden. Year 2013, she has appointed Adjunct Professor at the Department of Medical Biochemistry and Microbiology, Uppsala Unversity, Sweden. Dr Heldin’s interests are focused on understanding the mechanisms of how hyaluronan-CD44 complexes interact with the receptors for the growth factors PDGF and TGFβ for modulation of the proliferative and invasive behavior of malignant cells.

• 1.Emerging Roles for Hyaluronidase in Cancer Metastasis and Therapy2.Targeting Hyaluronic Acid Family for Cancer Chemoprevention & Therapy3.Aberrant Post-Transcriptional Processing of Hyaluronan Synthase 1 in Malignant Transformation and Tumor Progression 4.Hyaluronan Synthases Post-Translational Regulation in Cancer5.Hyaluronon-Coated Extracellular Vesicles – A Novel Link Between Hyaluronan and Cancer6.Hyaluronan in the Healthy and Malignant Hematopoietic Microenvironment7.Hyaluronan Regulation of Endothelial Barrier Function in Cancer8.HAS2 and CD44 in Breast Tumorigenesis9.CD44 is a Multidomain Signaling Platform that Integrates Extracellular Matrix Cues with Growth Factor and Cytokine Signals10.Hyaluronan-CD44 Interaction Promotes Oncogenic Signaling, MicroRNA Functions, Chemoresistance and Radiation Resistance in Cancer Stem Cells Leading to Tumor Progression11.Advances and Advantages of Nanomedicine in the Pharmacological Targeting of Hyaluronan-CD44 Interactions and Signaling in Cancer12.Hyaluronan / RHAMM Interactions in Mesenchymal Tumor Pathogenesis: Role of Growth Factors13.CD147: Regulator of Hyaluronan Signaling in Invasiveness and Chemoresistance