Huntington’s Disease

Inbunden, Engelska, 2018

AvSophie V. Precious,Anne E. Rosser,Stephen B. Dunnett

4 119 kr

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This detailed book provides a laboratory manual and guidebook for the selection, implementation, and interpretation of a wide range of techniques in contemporary use in leading laboratories engaged in Huntington’s disease (HD) research worldwide.

Produktinformation

Utgivningsdatum2018-06-01
Mått178 x 254 x 41 mm
Vikt1 419 g
FormatInbunden
SpråkEngelska
SerieMethods in Molecular Biology
Antal sidor642
Upplaga18001
FörlagHumana Press Inc.
ISBN9781493978243

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Stereological Methods to Quantify Cell Loss in the Huntington’s Disease Human Brain.- Assessing Autophagic Activity and Aggregate Formation of Mutant Huntingtin in Mammalian Cells.- A Filter Retardation Assay Facilitates the Detection and Quantification of Heat-Stable, Amyloidogenic Mutant Huntingtin Aggregates in Complex Biosamples.- Cellular Models: HD Patient-Derived Pluripotent Stem Cells.- Non-Mammalian Models of Huntington’s Disease.- Mouse Models of Huntington’s Disease.- Motor Assessment in Huntington’s Disease Mice.- Automated Operant Assessments of Huntington’s Disease Mouse Models.- Neurophysiological Assessment of Huntington’s Disease Model Mice.- Murine Models of Huntington’s Disease for Evaluating Therapeutics.- Generating Excitotoxic Lesion Models of Huntington’s Disease.- Large-Brained Animal Models of Huntington’s Disease: Sheep.- Minipigs as Large-Brained Animal Model for Huntington’s Disease: From Behavior and Imaging to Gene Therapy.- Non-Human Primate Models of Huntington’s Disease and Their Application in Translational Research.- In Vivo Multidimensional Brain Imaging in Huntington’s Disease Animal Models.- Magnetic Resonance Imaging in Huntington’s Disease.- Biofluid Biomarkers in Huntington’s Disease.- Assessing and Modulating Kynurenine Pathway Dynamics in Huntington’s Disease: Focus on Kynurenine 3-Monooxygenase.- Assessing Mitochondrial Function in In Vitro and Ex Vivo Models of Huntington’s Disease.- Using Genomic Data to Find Disease-Modifying Loci in Huntington’s Disease (HD).-CRISPR/Cas9-Mediated Genome Editing for Huntington's Disease.- Methods for Assessing DNA Repair and Repeat Expansion in Huntington’s Disease.- Translating Antisense Technology into a Treatment for Huntington’s Disease.- Disease Modification through Trophic Factor Delivery.- Methods to Quantify Cell Signaling and GPCR Receptor Ligand Bias: Characterization of Drugs that Target the Endocannabinoid Receptors in Huntington’s Disease.- Dissection and Preparation of Human Primary Fetal Ganglionic Eminence Tissue for Research and Clinical Application.- Robust Induction of DARPP32-Expressing GABAergic Striatal Neurons from Human Pluripotent Stem Cells.- Quality Assessment and Production of Human Cells for Clinical Use.