This book offers a rich repertoire of theoretical and pragmatic tools to address mounting economic, social, political, cultural, and environmental challenges and crises. It makes a compelling call for the need of innovation, experimentation, cross-sectoral collaboration, and multidisciplinary approaches. A must-read for anyone in civil society, academia, or subnational, regional, and national governments grappling with the need for new solutions and analytical frames. Besides constituting a practical toolkit, the case studies and snapshots from across the globe are also a timely and compelling case for the potential utility of human rights on the ground at a moment in which their relevance and impact are questioned.