Human Reproductive and Prenatal Genetics

Häftad, Engelska, 2018

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Human Reproductive and Prenatal Genetics presents the latest material from a detailed molecular, cellular and translational perspective. Considering its timeliness and potential international impact, this all-inclusive and authoritative work is ideal for researchers, students, and clinicians worldwide. Currently, there are no comprehensive books covering the field of human reproductive and prenatal genetics. As such, this book aims to be among the largest and most useful references available.

Named a Highly Commended book in the Basic and Clinical Sciences by the British Medical Association.

Features chapter contributions from leading international scientists and clinicians
Provides in-depth coverage of key topics in human reproductive and prenatal genetics, including genetic controls, fertilization and implantation, in vitro culture of the human embryo for the study of post-implantation development, and more
Identifies how researchers and clinicians can implement the latest genetic, epigenetic, and -omics based approaches

Produktinformation

Utgivningsdatum2018-08-29
Mått191 x 235 x 37 mm
Vikt1 680 g
FormatHäftad
SpråkEngelska
Antal sidor709
FörlagElsevier Science
ISBN9780128135709

Tillhör följande kategorier

Medicinsk genetik inom Medicin
Biovetenskap inom Naturvetenskap och teknik
Reproduktionsmedicin inom Medicin

Dr. Leung is a Professor at the University of British Columbia’s Department of Obstetrics & Gynecology and former Associate Dean in the Faculty of Medicine at UBC. Dr. Leung received his PhD from Western University. After post-doctoral training at the University of California at Los Angeles and the Laval University, he joined the University of British Columbia in 1982 as a faculty member. Dr. Leung has received a number of prestigious awards, including a Scholar Award and a Scientist Award from the Medical Research Council of Canada, a Distinguished Scholar Award from the Michael Smith Foundation for Health Research and a Senior Scientist Award from the BC Children Hospital Research Institute. Dr. Leung has served on many national and international organizations, including as President of the Canadian Fertility and Andrology Society, Director of the Society for the Study of Reproduction, Director of the Ovarian Workshops in the USA, temporary advisor to the World Health Organization, Fellow of the Canadian Academy for Health Sciences, and Fellow of the Royal Society of Canada. Dr. Leung’s research focuses on hormonal determinants of women’s reproductive health. His publication record to date includes 400 papers, 350 abstracts, 22 book chapters and 7 monographs. Since his appointment at UBC, Dr. Leung has served as the research supervisor for more than 100 graduate students, postdoctoral fellows and visiting scientists. Dr. Jie Qiao is the Chief Scientist of the Ministry of Science and Technology of China, the Incumbent Director of the North Third Hospital Department of Obstetrics and Gynecology, the Chinese Medical Association branch chairman for Reproductive Medicine, and the Beijing Medical Association branch chairman for Reproductive Medicine. She has been engaged in reproductive health-related clinical and basic research throughout her career, including as a visiting scholar at the University of Hong Kong and as a post-doctoral researcher at Stanford University. Her research has focused on gametes fertilization, infertility and embryo implantation mechanisms, and polycystic ovary syndrome pathogenesis among other topics. Dr. Jie Qiao has published more than 250 paper publications in peer reviewed journals on topics related to reproductive health.

Part I. Reproductive Tract Development and Gametogenesis1. Developmental Genetics of the Male Reproductive System2. Genetics and genomics of early gonad development3. Genetics of Meiotic Chromosome Dynamics and Fertility4. Effects of Aging on Sperm Chromatin5. In Vitro Spermatogenesis from Pluripotent Stem Cells6. Developmental Genetics of the Female Reproductive Tract7. The Molecular Genetics of Oogenesis8. Epigenetic Control of Oocyte Development9. RNA Binding Protein Networks and Translational Regulation in Oocytes10. Translational Regulation of Gene Expression during Oogenesis and Pre-implantation Embryo Development11. MicroRNAs in Gametes and Preimplantation Embryos: Clinical ImplicationsPart II. Embryo Implantation, Placenta Development and Pregnancy12. Transcriptomics of the Human Endometrium and Embryo Implantation13. Epigenetic Modifications in the Human Placenta 14. microRNAs in pregnancy: implications for basic research and clinical management15. Genetics and Genomics of Preterm Birth16. The Intergenerational Effects on Fetal ProgrammingPart III. Infertility and Assisted Reproductive Technology17. Genetic Testing in Male Infertility18. Genetics and Genomics of Endometriosis19. Genetics and Genomics of Primary Ovarian Insufficiency20. Genetics of Polycystic Ovary Syndrome21. Genetics and Genomics of Recurrent Pregnancy Loss22. Human Genetics and Assisted Reproduction in Endometriosis23. Uterine Transplantation Part IV. Preimplantation/Prenatal Genetic Diagnosis and Screening24. Epidemiology and Genetics of Human Aneuploidy25. Next Generation Sequencing for Gene Panels and Clinical Exomes26. Chromosomal Microarrays and Exome Sequencing for Diagnosis of Fetal Abnormalities27. Noninvasive Prenatal Testing for Genetic Diseases28. Non-Invasive Prenatal Testing by Cell-Free DNA: Technology, Biology, Clinical Utility and Limitations29. Prenatal diagnosis and treatment of genetic steroid disorders30. Application of Gene-Editing Technologies in Embryos and Their Potential for Gene Therapy