Del 5 - Foundation of Human Biology

Human Population Genetics

Häftad, Engelska, 2012

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Introductory guide to human population genetics and microevolutionary theoryProviding an introduction to mathematical population genetics, Human Population Genetics gives basic background on the mechanisms of human microevolution. This text combines mathematics, biology, and anthropology and is best suited for advanced undergraduate and graduate study.Thorough and accessible, Human Population Genetics presents concepts and methods of population genetics specific to human population study, utilizing uncomplicated mathematics like high school algebra and basic concepts of probability to explain theories central to the field. By describing changes in the frequency of genetic variants from one generation to the next, this book hones in on the mathematical basis of evolutionary theory.Human Population Genetics includes: Helpful formulae for learning ease Graphs and analogies that make basic points and relate the evolutionary process to mathematical ideas Glossary terms marked in boldface within the book the first time they appear In-text citations that act as reference points for further research Exemplary case studies Topics such as Hardy-Weinberg equilibrium, inbreeding, mutation, genetic drift, natural selection, and gene flow Human Population Genetics solidifies knowledge learned in introductory biological anthropology or biology courses and makes it applicable to genetic study.NOTE: errata for the first edition can be found at the author's website: http://employees.oneonta.edu/relethjh/HPG/errata.pdf

Produktinformation

Utgivningsdatum2012-04-13
Mått179 x 254 x 18 mm
Vikt544 g
FormatHäftad
SpråkEngelska
SerieFoundation of Human Biology
Antal sidor324
FörlagJohn Wiley and Sons Ltd
ISBN9780470464670

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Dr. John H. Relethford (Distinguished Teaching Professor) is a biological anthropologist who received his Ph.D. in anthropology in 1980 from the State University of New York at Albany. Dr. Relethford's major interests are in the fields of anthropological genetics, human variation, and modern human origins. Much of his research has focused on the reconstruction of history from patterns of modern biological variation. His past work has also included studies of migration, quantitative genetics, child growth, epidemiology, and aging. His current work focuses on two topics, the evolutionary history of Irish populations and the origin of modern humans.

Foreword viiPreface ix1 Genetic, Mathematical, and Anthropological Background 1I. The Scope of Population Genetics 2II. Genetics Background 5III. Principles of Probability 14IV. The Anthropological Connection 17V. A Closing Thought 212 Hardy–Weinberg Equilibrium 23I. Genotype and Allele Frequencies 24II. What is Hardy–Weinberg Equilibrium? 30III. The Mathematics of Hardy–Weinberg Equilibrium 31IV. Using Hardy–Weinberg Equilibrium 37V. Extensions of Hardy–Weinberg Equilibrium 40VI. Hardy–Weinberg Equilibrium and Evolution 44VII. Summary 453 Inbreeding 49I. Quantifying Inbreeding 51II. Population Genetics and Inbreeding 62III. Inbreeding in Human Populations 65IV. Summary 754 Mutation 77I. The Nature of Mutations 77II. Models of Mutation 81III. Mutational History and Anthropological Questions 88IV. Summary 965 Genetic Drift 101I. What is Genetic Drift? 102II. Genetic Drift and Population Size 112III. Effects on Genetic Variation 120IV. Mutation and Genetic Drift 121V. Coalescent Theory 125VI. Summary 1316 Models of Natural Selection 139I. How Does Natural Selection Work? 140II. A General Model of Natural Selection 145III. Types of Natural Selection 147IV. Other Aspects of Selection 160V. Summary 1677 Natural Selection in Human Populations 181I. Case Studies of Natural Selection in Human Populations 182II. Are Humans Still EvolVIng? 198III. Summary 2038 Gene Flow 205I. The Evolutionary Impact of Gene Flow 206II. Models of Gene Flow 208III. Gene Flow and Genetic Drift 213IV. Estimating Admixture in Human Populations 226V. Summary 2309 Human Population Structure and History 237I. Case Studies of Human Population Structure 238II. The Origin of Modern Humans 242III. Case Studies of Population Origins 247IV. Summary 255Glossary 257References 267Index 279

“Relethford’s Human Population Geneticsis a superb attempt at facing the challenges of explaining the basics of population genetics to those with a limited background in evolutionary theory and a fear of the quantitative.” (The Quarterly Review of Biology, 1 September 2014)“For many students, and likely some instructors, who have found the mathematical underpinnings of evolutionary genetics daunting, this new volume will be a welcome addition to the bookshelf. It is an easy book to recommend either as a primary text in anthropological genetics courses, or as a recommended or adjunct text in upper division/beginning graduate courses in human biology, human genetics, or human evolution.” (American Journal of Physical Anthropology, 19 September 2013)