Human Embryos and Preimplantation Genetic Technologies

Dr. Scott Sills is Senior Vice President for Research at Gen 5 Fertility in La Jolla, Califormia. In addition to full-time IVF practice, Dr. Sills' research portfolio focuses on reproductive genetics, bioethics, minimal access fertility surgery, and health policy. At G5F, Dr. Sills continues to standardize ovarian ‘rejuvenation’ using autologous platelet-rich plasma, following the first registered clinical trial of its kind for which he was Principal Investigator (2017-2018). Dr. Sills is a Vanderbilt graduate and received his PhD from London’s University of Westminster. He was awarded the MD degree from University of Tennessee in 1992, followed by gynecology residency at NYU Downtown Hospital and a sub-specialty fellowship in reproductive endocrinology at Cornell University-New York Presbyterian Hospital. He is board certified both by the American Board of Obstetrics & Gynecology and the National Board of Physicians & Surgeons. Dr Sills is a Fellow of the American College of Obstetricians & Gynecologists, American College of Surgeons, and the Royal College of Physicians (Ireland), with medical credentials in California, New York and the United Kingdom. Gianpiero D. Palermo, MD, PhD is Director of Assisted Fertilization and Andrology at the Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine (CRM), Professor of Embryology in Obstetrics & Gynaecology, and the Blavatnik Distinguished Professor of Reproductive Medicine at Weill Cornell Medical College. Dr. Gianpiero Palermo is internationally known as an innovator in reproductive medicine, having developed intracytoplasmic sperm injection (ICSI), a revolutionary procedure in which a single sperm is injected directly into the egg for fertilization. In recognition of his ground-breaking contribution to reproductive medicine, he has received prestigious awards, including the Serono Prize for Medical Research on chromosomal analysis of embryos; the Barbara Eck Menning Founder's Award from RESOLVE, the national infertility organization; the Shackman Memorial Lecture at Johns Hopkins; the Buckeye Lecture of the American Society of Andrology; the Jacob Heskel Gabbay Award in Biotechnology and Medicine; and the Russian Crystal Tube Award. His current research includes molecular and genetic aspects of fertilization, follow-up of ICSI babies, and genetic aspects of male infertility, as well as devising new procedures to treat age-related female infertility, harvesting and differentiation of embryonic stem cells and in vitro maturation of male germ cells.

• 1. The challenge for medical ethicists: Weighing pros and cons of advanced reproductive technologies to screen human embryos during IVFInmaculada de Melo-Martın2. Too much information? The paradox of enlarging genetic datasets for human embryo assessment during in vitro fertilization (IVF)Shachar Zuckerman and Gheona Altarescu3. A new global perspective: Geographic variations in the use of preimplantation genetic technologies to screen human embryosAlexander M. Quaas4. Elective gender selection of human embryos during IVF: Ethical and public policy considerationsGab Kovacs5. Embryo mosaicism and its impact on IVF decisionmaking when using preimplantation genetic screening: Current challenges and controversiesGon Shoham, Yuval Yaron and Ariel Weissman6. Genetic counseling for preimplantation genetic testing (PGT): Practical and ethical challengesEmily L. Mounts and Andria G. Besser7. Psychological and interpersonal factors in preimplantation embryo assessmentTimothy Bracewell-Milnes, Jara Ben-Nagi and Meen-Yau Thum8. Nonideal theory, self-respect, and preimplantation genetic technologiesClair Morrissey and Elena Neale9. Fate of non-transferred screened embryos from IVF: Current challenges and future directionsAlice J. Shapiro, Catherine Shea and Vitaly A. Kushnir10. The Islamic perspective: Application of advanced reproductive technologies to screen human embryos during IVFGamal I. Serour and Ahmad G.I. Serour11. An Orthodox Jewish approach to ethical and social aspects of embryo testingGideon Weitzman, Lior Segev and Benjamin David12. The Australia experience: Cultural and political factors shaping human embryo assessment during in vitro fertilizationBrette Blakely, Tereza Hendl and Sheryl de Lacey13. The Belgian experience: Cultural and political factors shaping preimplantation genetic diagnosis during in vitro fertilizationGuido Pennings and Heidi Mertes14. The Brazil experience: Evolution and future trajectories of public health policy regarding human embryo assessmentFernanda Souza Peruzzato and Juliana Cuzzi15. The Chilean experience: Cultural and political factors shaping human embryo assessment during IVFFernando Zegers-Hochschild and Juan Enrique Schwarze16. The Croatian experience: Cultural and political factors shaping human embryo assessment during assisted reproductive technologyTamara Tramisak Milakovic and Ivana Milas Klaric17. The Ireland experience: Cultural and political factors shaping the development of regulation of assisted human reproduction, ethical status of human embryos, and proposed regulation of surrogacyEvelyn Mahon18. The Thailand experience: Cultural and political factors shaping human embryo assessment during IVFPatsama Vichinsartvichai19. The Ukraine experience: Preimplantation testing of human embryosLyuda V. Shkrobot20. Mitochondrial replacement therapy: Ethical, sociocultural, and public policy considerationsShelley Dolitsky and Mark V. Sauer21. Editing human reproduction? Legal and ethical aspects of genome editingJudit Sandor