This book constitutes the refereed proceedings of the First International Workshop, HAIC 2025, held in Conjunction with MICCAI 2025, Daejeon, South Korea, in September 27, 2025.The 9 full papers presented in this book were carefully selected and reviewed from 12 submissions. These papers have been organized in the following topical sections:Medical image computing; computer-assisted intervention; human-ai collaboration; human-computer interaction; human factor modeling; medical image analysis.