How to Scale-Up a Wet Granulation End Point Scientifically

Michael Levin has over 30 years of experience in the field of pharmaceutical scale-up, instrumentation and process optimization. He has edited a “Pharmaceutical Process Scale-Up” book, and has contributed chapters on “Tablet Press Instrumentation” and “Wet Granulation: End-Point Determination and Scale-Up” in the Encyclopedia of Pharmaceutical Technology. Michael holds a M.Sc. degree in History and Philosophy of Science from Hebrew University of Jerusalem and Ph.D. in BioMathematics (1980) from University of Washington in Seattle. His Post Doctorate studies were at University of Houston, Department of Mechanical Engineering. He participated in numerous wet and dry granulation and tableting projects in major pharmaceutical companies as a provider of process analytical instrumentation, conducted many seminars, performed numerous consulting services and wrote expert reports to clients in the pharmaceutical industry.

• 1. Scale-Up Basics2. Dimensional Analysis, Principle of Similitude, Dimensionless Numbers, Comparison of attainable Froude Numbers3. Scientific scale-up procedure4. Case Studies5. Practical Considerations for End-Point Scale-Up6. List of Symbols and Dimensions, Literature Reference