Hoffbrand's Postgraduate Haematology

Adam J Mead PhD, FRCP, FRCPath, FMedSci Haematopoietic Stem Cell Biology Laboratory, Medical Research Council Molecular Haematology Unit, Medical Research Council Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK Michael A Laffan DM, MRCP, FRCPath Department of Immunology and Inflammation, Faculty of Medicine, Imperial College London, London, UK Graham P Collins DPhil, FRCP, FRCPath Department of Haematology, Oxford Cancer and Haematology Centre, Oxford, UK Deborah Hay DPhil, MRCP, FRCPath Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, Oxford, UK Consulting Editor A Victor Hoffbrand MA, DM, FRCP, FRCPath, FRCP (Edin), DSc, FMedSci Emeritus Professor of Haematology, University College London, London, UK Honorary Consultant Haematologist, Royal Free Hospital, London, UK

• About the Editors viiiContributor’s List xPreface to the eighth edition by Adam J Mead xivPreface to the eighth edition by A Victor Hoffbrand xvPreface to the first edition xviAbout the companion website xviiPart I General principles of haematology 11 Human stem cells and haemopoiesis 3Petter S Woll and Adam J Mead2 Phagocytes 15Fernando O Martinez, Giuseppe Teti and Siamon Gordon3 Erythropoiesis in the human 43Douglas R Higgs, Christian Babbs and Mira Kassouf4 Lymphocyte development and function 56Sean Hua Lim5 The spleen 71Catherine Hildyard and Daniel Royston6 Cancer immunotherapy 82Charlotte O’Brien-Gore, Sophie Papa and Shahram Kordasti7 Clinical applications of gene editing and therapy 96Mohsin Badat and James Davies8 Application of next-generation sequencing in haematology 106Angela Hamblin and Adele Timbs9 The molecular basis of haematological malignancies 121Meng Wang, Niccolo Bolli and George S Vassiliou10 Laboratory diagnosis of haematological neoplasms 142Barbara J Bain and Torsten HaferlachPart II Red blood cell disorders and blood transfusion 16311 Iron metabolism, iron deficiency and disorders of haem synthesis 165Clara Camaschella and Chaim Hershko12 Iron overload 188Clara Camaschella and Maria Domenica Cappellini13 Megaloblastic anaemia 201A Victor Hoffbrand14 Haemoglobin and the inherited disorders of globin synthesis 222Swee Lay Thein and David Rees15 Sickle cell disease 249Neha Bhasin and Elliott P Vichinsky16 Hereditary disorders of the red cell membrane and disorders of red cell metabolism 269Paola Bianchi and Narla Mohandas17 Acquired haemolytic anaemias 292Rachel Kesse-Adu and Anietie Ekong18 Red cell immunohaematology 309Nicole Thornton, Tom Bullock and Shubha Allard Copyrighted Material19 Clinical blood transfusion 328Andrew Charlton, Shruthi Narayan and Shubha AllardPart III Lymphoid disorders 36120 The classification of lymphomas 363Elias Campo, Gerard Frigola and Stefano A Pileri21 Adult acute lymphoblastic leukaemia 395Clare J Rowntree and Adele K Fielding22 Childhood acute lymphoblastic leukaemia 409Sujith Samarasinghe, Anthony Moorman and Ajay Vora23 Chronic lymphocytic leukaemia and other chronic B-cell lymphoproliferative disorders 428Emili Montserrat24 T-cell lymphoma and lymphoproliferative disorders 452Alessandro Broccoli and Pier Luigi Zinzani25 Hodgkin lymphoma 468Beth Phillips and Graham P Collins26 Indolent non-Hodgkin lymphomas 482Kim Linton and William Townsend27 Aggressive B-cell non-Hodgkin lymphoma 501Matthew R Wilson, Jessica Okosun and Kate Cwynarski28 Multiple myeloma 524Karthik Ramasamy and Sagar Lonial29 Amyloidosis 547Ashutosh D WechalekarPart IV Stem cell and myeloid disorders 56130 Inherited aplastic anaemia/bone marrow failure syndromes 563Inderjeet S Dokal31 Acquired aplastic anaemia and paroxysmal nocturnal haemoglobinuria 583Austin G Kulasekararaj, Neal S Young and Judith CW Marsh32 Acute myeloid leukaemia 605Tumas Beinortas, Paolo Gallipoli and Brian J P Huntly33 Chronic myeloid leukaemia 630David T O Yeung and Timothy P Hughes34 The myelodysplastic syndromes 652Johanna Ungerstedt, Magnus Tobiasson and Eva Hellström Lindberg35 Myeloproliferative neoplasms 673Claire N Harrison, Anna L Godfrey, Mary Frances McMullin and Deepti H Radia36 Macrophages, dendritic cells and histiocytic disorders 704Matthew Collin, Venetia Bigley and Chris Bacon37 Stem cell transplantation 719Charles Craddock and Ronjon Chakraverty38 Clonal haematopoiesis 745Margarete A Fabre and George S VassiliouPart V Haemostasis and thrombosis 75739 Normal haemostasis 759Keith Gomez and John H McVey40 The vascular function of platelets 782Stephen P Watson, Neil V Morgan, Paul Harrison and Gillian Lowe41 Haemophilia and von Willebrand disease 798Michael A Laffan42 Rare inherited coagulation disorders 819Flora Peyvandi and Marzia Menegatti43 Acquired coagulation disorders 829Peter W Collins and Jecko Thachil44 Congenital platelet disorders 848Maurizio Margaglione and Paul RJ Ames45 Primary immune thrombocytopenia 861Nichola Cooper and Drew Provan46 Thrombotic thrombocytopenic purpura (congenital and acquired) and haemolytic–uraemic syndrome 872Pier Mannuccio Mannucci, Massimo Cugno and Flora Peyvandi47 Antithrombotic agents 886Jeffrey I Weitz48 Pathogenesis of venous thromboembolism 902Henry G Watson49 Prevention and management of venous thromboembolism 921Nicola Curry and Susan Shapiro50 Pathogenesis and management of arterial thrombosis 932Willem L Bor, Dean RPP Chan Pin Yin, Jurriën M ten Berg, Constance Baaten and Hugo ten CatePart VI Consultative haematology, supportive care and miscellaneous disorders 94751 Haematological aspects of conditions that occur primarily in tropical countries 949Imelda Bates and Ivy Ekem52 Lysosomal storage disorders 966Derralynn A Hughes53 Obstetric haematology 974Gillian Swallow and Sue Pavord54 Neonatal haematology 989Irene Roberts and Subarna Chakravorty55 Supportive care in the management of leukaemia 1005Renuka Palanicawandar and Jirí Pavlů56 General consultative haematology 1024John Willan57 Consultative haemostasis and thrombosis 1036Michael A Laffan and Peter MacCallumIndex 1055

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