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This volume summarizes recent advances in understanding the mechanisms of HIV-1 latency, in characterizing residual viral reservoirs, and in developing targeted interventions to reduce HIV-1 persistence during antiretroviral therapy. assays and technical approaches to quantify viral reservoirs in humans and animal models;
Guido SilvestriEmory University School of Medicine, Atlanta, GA 30329, USAgsilves@emory.eduMathias LichterfeldThe Brigham and Women’s Hospital and the Ragon Institute of MGH, MIT and Harvard, Boston, MA, USAMLICHTERFELD@mgh.harvard.edu
Molecular Control of HIV and SIV Latency.- Assays to Measure Latency, Reservoirs and Reactivation.- The Antiviral Immune Response and its Impact on the HIV-1 Reservoir.- Nonhuman Primate Models for Studies of AIDS Virus Persistence During Suppressive Combination Antiretroviral Therapy.- SIV Latency in Macrophages in the CNS.- Mathematical models of HIV latency.- Residual Immune Activation and Latency.- Immune Interventions to Eliminate the HIV Reservoir.- Cell and Gene Therapy for HIV Cure.
