Histone Deacetylases in Neurodegenerative Disease Part A

After completing studies for the A.B., A.M., and Ph.D. degrees in chemistry at Harvard University, David W. Christianson joined the faculty of the University of Pennsylvania, where he is currently the Roy and Diana Vagelos Professor in Chemistry and Chemical Biology. At Penn, Christianson’s research focuses on the structural and chemical biology of the zinc-dependent histone deacetylases as well as enzymes of terpene biosynthesis. His research accomplishments have been recognized by several awards, including the Pfizer Award in Enzyme Chemistry and the Repligen Award in Chemistry of Biological Processes from the American Chemical Society, a Guggenheim Fellowship, and the Elizabeth S. and Richard M. Cashin Fellowship from the Radcliffe Institute for Advanced Study at Harvard University. Christianson is also a dedicated classroom teacher, and his accomplishments in this regard have been recognized by the Lindback Award for Distinguished Teaching at Penn and a Rhodes Trust Inspirational Educator Award from Oxford University. Christianson has also held visiting professorships in the Department of Biochemistry at Cambridge University and the Department of Chemistry and Chemical Biology at Harvard University. Christianson has served with Prof. Anna Pyle as Co-Editor-in-Chief of Methods in Enzymology since 2015.Dr. Karen N. Allen works at the Department of Chemistry of the Boston University, the Metcalf Center for Science and Engineering Subashchandrabose Chinnathambi is Additional Professor Department of Neurochemistry National Institute of Mental Health and Neurosciences Hospital Bangalore, Karnataka, India.

• 1. HDAC Inhibitor-Induced Endoplasmic Reticulum (ER) StressChristian Marx2. Specific activation of p300/CBP Lysine acetyltransferases induces adult neurogenesis and synaptic plasticityTapas K. Kundu3. Chromatin immunoprecipitation assay for analyzing histone H3-mediated regulation of copper homeostasisRaghuvir Singh Tomar, Rakesh Kumar Sahu and Sakshi Singh4. Histone Deacetylase 6 modulates Tau structure and functionSubashchandrabose Chinnathambi5. Histone Acetylation in Parkinson DiseaseZhuohua Zhang6. DNA methylation and histone modification in hypoxic conditionsSanjeev Shukla7. The extracellular Histone Deacetylase 6 modulates the actin networks in neuronal cellsSubashchandrabose Chinnathambi8. Epigenetic modulators as therapeutics for neurodegenerative disorder/Alzheimers diseaseBalaram Ghosh9. Sirtunins in mitochondrial physiology and energy homeostasisUllas Kothur-Seetharam10. Sirtunins in metabolic homestasisNagalingam Ravi Sundaresan11. Conformational flexibility of histone variant CENP-ACse4 is regulated by histone H4: A mechanism to stabilize soluble Cse4Ashutosh Kumar12. Analysis of copper toxicity by western blotting of secretory proteins translocated via Sec61 channelRaghuvir Singh Tomar, Smriti Anand, Prateeksha Thakur, Vandana Anjana, Santoshi Acharjee, Rajshree Pal and Sugandh Sharma13. Histone deacetylase as a potential therapeutic target for memory disordersMahendra Kumar Thakur14. Histone deacetylases in NeurodegenerationAmit Mishra15. Role of Deubiquitinases in Regulating Tau Acetylation and Autophagic Clearance in Alzheimer’s DiseasePoornima Priyadarshini16. Histone deacetylases in Neurodegeneration and neuronal plasticityBhupesh Mehta17. Experimental strategies to evaluate the impact of HDACs on the epigenome: The ChiP-seqClaudio Brancolini and Martina Minisini18. Difluoromethyl-1,3,4-oxadiazoles are slow-binding substrate analog inhibitors of histone deacetylase 6 with unprecedented isotype selectivityChristian Steinkühler