Histamine Receptors

Preclinical and Clinical Aspects

Inbunden, Engelska, 2025

Av Patrizio Blandina, Maria Beatrice Passani, Gustavo Provensi

3 649 kr

Beställningsvara. Skickas inom 10-15 vardagar

Fri frakt för medlemmar vid köp för minst 249 kr.

This new edition provides a comprehensive and authoritative overview of the current state of both preclinical and clinical research on histamine and its receptors. It explores novel investigative approaches, including receptor polymorphisms, genetic linkage analysis, and computational modeling. Additionally, it examines the application of new histaminergic ligands in the treatment of various diseases, such as asthma and atopic dermatitis.Several chapters are dedicated to the role of histamine in regulating homeostatic and behavioral functions, including the sleep–wake cycle, appetite control, alertness, pruritus (itch), and the processes of memory formation and consolidation.This edition also introduces newly added chapters focusing on the roles of histamine and its receptors in the kidneys and eyes, both in physiological and pathological contexts, as well as their involvement in motivational processes.

Produktinformation

Utgivningsdatum2025-09-27
Mått155 x 235 x 19 mm
Vikt528 g
FormatInbunden
SpråkEngelska
SerieReceptors
Antal sidor227
Upplaga2
FörlagSpringer International Publishing AG
ISBN9783031989209

Tillhör följande kategorier

Onkologi inom Medicin
Biovetenskap inom Naturvetenskap och teknik

Patrizio Blandina, MD, Professor, Department of Neurosciences, Psychology, Drug Research and Child Health (NEUROFARBA), University of Florence, Florence, Italy.Maria Beatrice Passani, PhD, Professor, Department of Health Sciences (DSS), University of Florence, Florence, Italy.Gustavo Provensi, PhD, Professor, Department of Neurosciences, Psychology, Drug Research and Child Health (NEUROFARBA), University of Florence, Florence, Italy.

Molecular aspects of histamine receptors.- Genetic polymorphisms in the histamine receptor family.- The role of the histamine H4 receptor in asthma and atopic dermatitis.- Identification and roles of zebrafish histamine receptors.- Histamine H3r antagonists: from scaffold hopping to clinical candidates.- Clinical significance of histamine H1 receptor gene expression and drug action of antihistamines.- Histamine and its receptors as a module of the biogenic amine diseasome.- Histaminergic regulation of blood-brain barrier activity.- Histamine function in nervous systems.- Heterogeneity of histaminergic neurons.- Modulation by histamine H3 receptors of neurotransmitter release in the basal ganglia.- Interaction of brain histaminergic and dopaminergic systems.- Histamine H1 Receptor Occupancy in Human Brain Measured by Positron Emission Tomography.- Modulation of memory consolidation and extinction by brain histamine.- Histamine and appetite.