This bookconstitutes the proceedings of the Second Latin American Conference on HighPerformance Computing, CARLA 2015, a joint conference of the High-PerformanceComputing Latin America Community, HPCLATAM, and the Conferencia LatinoAmericana de Computación de Alto Rendimiento, CLCAR, held in Petrópolis,Brazil, in August 2015. The 11papers presented in this volume were carefully reviewed and selected from 17 submissions. They were organized in topical sections named: grid andcloud computing; GPU & MIC Computing: methods, libraries and applications;and scientific computing applications.