Hepatology

Dr. Jenny Heathcote, MB.BS, M.D, FRCP, FRCP, is Professor of Medicine at the?University of Toronto. She graduated from the Royal Free Hospital School of Medicine, London, UK in 1968. After completing internship and residency in internal medicine, she moved to Stanford, USA for further research training and joined the Toronto Western Hospital, where she has since built up an internationally recognized clinical liver research unit with a major interest in viral hepatitis and autoimmune liver disease. She is a Senior Scientist in the Toronto Western Research Institute where she is Division Head of "Patient Based Clinical Research".Dr. Heathcote has been a Professor at the University of Toronto since 1995, winning numerous awards in a stellar career, including:?Queen's Jubilee Medal for services to hepatology;?Canadian Liver Foundation Gold Medal at the Canadian Digestive Diseases Week in 2004; the Canadian Liver Foundation Lifetime Achievement Award 2004; American Association for the Study of Liver Diseases Distinguished Achievement Award 2005;?International Sheila Sherlock Award from the Falk Foundation 2006.She was funded from 2003 — 2009 by the Canadian?Institutes of Health Research, and was Director of the CIHR funded National Canadian Research Training Program in Hepatitis C. She now heads up the NIH funded Toronto site for the North American Clinical network for chronic hepatitis B.She has published over 200 papers in the area of autoimmune liver disease and chronic viral hepatitis.

• Contributors ixForeword xiiPreface xivAcknowledgements xv1 Clinical Assessment of the Adult Patient with Possible Liver Disease: History and Physical Examination 1Eberhard L. Renner2 Initial Diagnosis, Workup, and Assessment of Severity of Liver Disease in Adults 13Scott K. Fung3 Pediatric Liver Disease: An Approach to Diagnosis and Assessment of Severity 31Binita M. Kamath and Vicky L. Ng4 Natural History of the Cirrhotic Patient 45Jordan J. Feld5 Management of Complications of Portal Hypertension in Adults and Children: Variceal Hemorrhage 63E. Jenny Heathcote Simon Ling and Binita M. Kamath6 Management of Ascites 80David K.H. Wong7 Masses in the Liver 93Morris Sherman8 Chronic Portosystemic Encephalopathy and Its Management 112Leslie B. Lilly and Binita M. Kamath9 Indications for Liver Transplantation in Adults and Children 119Nazia Selzner and Vicky L. Ng10 Management of Fulminant Hepatic Failure 132Leslie B. Lilly11 Management of the Complications of Liver Transplantation 142Eberhard L. Renner and Eve A. Roberts12 Acute Viral Hepatitis in Adults and Children: Hepatitis A, B, C, D, E, and Others 162Hemant A. Shah and Eve A. Roberts13 Chronic Viral Hepatitis in Adults and Children: Hepatitis B 185Jordan J. Feld14 Chronic Viral Hepatitis in Adults and Children: Hepatitis C 208Eberhard L. Renner and Eve A. Roberts15 Liver Disease Due to Alcohol 226Nazia Selzner16 Drug-Induced Liver Disease 235Leslie B. Lilly17 Obesity and Its Hepatic Complications in Adults and Children 244E. Jenny Heathcote and Eve A. Roberts18 HIV-Associated Liver Diseases 263David K.H. Wong19 Autoimmune Hepatitis in Adults and Children 281Gideon M. Hirschfield20 Chronic Cholestatic Liver Disease and Its Management in Adults and Children 297Gideon M. Hirschfield and Binita M. Kamath21 Vascular Diseases of the Liver 315Jordan J. Feld22 Approach to Metabolic and Storage Diseases 329Hemant A. Shah and Eve A. Roberts23 Wilson Disease: When Should You Think of Wilson Disease? 352Eve A. Roberts and Gideon M. Hirschfield24 Liver Disease in Pregnant Women 367E. Jenny Heathcote25 Cystic Disease of the Liver 383Morris Sherman26 An Internist’s Approach to Radiologic Examination of the Liver 396Anthony E. Hanbidge and Korosh KhaliliIndex 413