Series Editors Maurizio Cecconi is Head of Department Anaesthesia and Intensive Care Units, IRCCS Istituto Clinico Humanitas, Rozzano (MI), Italy and Professor of Anaesthesia and Intensive Care, Humanitas University, Pieve Emanuele (MI), Italy. His main fields of research are haemodynamic monitoring, haemodynamic optimisation and physiology of the critically ill patient. He has published extensively and has specific interest in haemodynamic monitoring and fluid management of the critically ill.Daniel De Backer is Professor of Intensive Care at the Université Libre de Bruxelles, Brussels, Belgium Head of Intensive Care Departments of CHIREC Hospitals (Brussels and Braine l’Alleud-Waterloo). His main fields of investigation are severe sepsis, organ dysfunction, acute circulatory failure and its treatment (in particular vasoactive agents), haemodynamic monitoring, hepato-splanchnic circulation and microcirculatory disorders.Volume EditorsMichael R. Pinsky has published >300 peer-reviewed papers, >250 chapters, and 24 volumes. In the Department of Critical Care Medicine at the University of Pittsburgh, he is the program director for Adult Critical Care Medicine T32 research training program, Director of the Cardiopulmonary Research Laboratory, Editor-in-Chief of WebMD’s Critical Care Medicine and on numerous editorial boards. His research on heart lung interactions and resuscitation physiology has brought major advances in the management of critically ill patients.Jean Louis Teboul is a Professor of Therapeutics and Critical Care Medicine at Paris South University. He is pioneer in clinical application of heart-lung interactions, tissue oxygenation, haemodynamic monitoring, and assessment of volume status in critically ill patients. He proposed new tests to assess fluid responsiveness such as Pulse Pressure Variation and Passive Leg Raising.Jean Louis Vincent is Professor of Intensive Care at University of Brussels. He is President of the World Federation of Societies of Intensive and Critical Care Medicine (WFSICCM) and a Past-President of the Belgian Society of Intensive Care Medicine (SIZ), the European Society of Intensive Care Medicine (ESICM), the European Shock Society