Heme Oxygenase in Biology and Medicine

Inbunden, Engelska, 2002

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The convergence of research in stem cell biology, leukaemic cell genetics and drug discovery has provided insight into pathogenesis and treatment of leukaemia and lymphoma. These insights have led to alternative therapeutic approaches involving the manipulation of molecular and/or biochemical pathways in leukaemia cells. Nonetheless, effective treatment and cures for these blood-related diseases remains, in many cases elusive. This symposium was designed to integrate knowledge regarding the basic cellular and molecular biology of leukaemia and lymphoma with alternative approaches to diagnosis and therapy. To this end, a translation research (laboratory to bedside) approach was encouraged throughout the meeting, with discussions covering new mechanisms regulating hematopeoietic cell development, data from clinical trails of new molecular therapeutics, and emerging directions in diagnosis. The symposium brings together basic, translational and clinical investigators in a meeting aimed at developing potential collaborative interaction. The intension is to provide new insights into the molecular targets for the treatment of blood-related cancers.

Produktinformation

Utgivningsdatum2002-08-31
Mått178 x 254 x 38 mm
Vikt1 324 g
FormatInbunden
SpråkEngelska
Antal sidor515
Upplaga2002
FörlagSpringer Science+Business Media
ISBN9780306472640

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Section I. Physiology/pathology of heme Oxygenase and its Products, Carbon Monoxide and Bilirubin.- 1. Development of Heme Oxygenase Inhibitors for the Prevention of Severe Jaundice in Infants: Studies from Laboratory Bench to New Nursery.- 2. Carbon Monoxide: A Potential Antiinflammatory Agent and Mediator of Lung Anti-Oxidant Defenses.- 3. Correlation of the Altered Vascular Effects of Carbon Monoxide and the Cardiovascular Complications of Diabetes.- 4. Endogenous Carbon Monoxide Has Protective Roles in Neointimal Development Elicited by Arterial Injury.- 5. End Tidal Breath Carbon Monoxide (ETCO) Levels in Pregnant Women.- 6. The Role of Heme Oxygenase in Pregnancy.- 7. Increased Carbon Monoxide in Exhaled Air in Patients with Inflammatory Respiratory Diseases.- 8. Carbon Monoxide and Iron, by Products of Heme Oxygenase, Modulate Vasular Endothelial Growth Factor Synthesis in Vascular Smooth Muscle Cells.- Section II. Physiological Function of heme Oxygenase and the central Nervous System.- 9. CO and Neonatal Cerebral Circulation.- 10. Differential Expression of Heme Oxygenase-1 in Rat Brain by Endotoxin (LPS).- 11. Role of Heme Catabolism in Neurodegenerative Diseases.- 12. Heme Oxygenase-1 and Alzheimer Disease.- 13. Early Molecular Mechanisms for the Induction of Neuronal Membrane Asymmetry and Genomic DNA Cleavage.- 14. Heme Oxygenase (HO)-1 Expressing Macrophages/Microglial Cells Accumulate during Oligodendroglioma Progression.- Section III. Clinical Omplications of heme Oxygenase System in Inflammation.- 15. Heme Oxygenase and Ocular Surface Inflammation.- 16. Targeted Expression of Heme Oxygenase-1 and Pulmonary Responses to Hypoxia.- 17. Heme Oxygenase in Skeletal Muscle: Role in Septic Diaphragmatic Failure.- 18. Heme Oxygenase-1 (HO-1): Multiple Effects ofa Protective Gene That Prevents Graft Rejection.- 19. Thioredoxin Facilitates The Induction of Heme Oxygenase-1 in Response to Inflammatory Mediators.- Section IV. Heme Oxygenase and Cardiovascular System.- 20. Induction of Heme Oxygenase-1 as a Protective Response Against Heme Protein-Induced Renal Injury.- 21. Regulation and Role of Heme Oxygenase-1 in Glomerulonephritis.- 22. Heme Oxygenase-1 Mediates Atrial Natriuretic Peptide Induced Protection of Renal Cells From Cyclosporin Toxicity.- 23. Heme Oxygenase and Atherosclerosis.- 24. Atherogenicity of Hypercholesterolemia in the Precense of Hemolysis in Spite of Heme Oxygenase-1 Induction: A Possible Consequence of its Interaction with Plasma Lipoproteins.- 25. Anti-Atherogenic Properties of Heme Oxygenase.- 26. Heme Oxygenase and the Novel Tumour-Specific Anti-Vascular Compound Combretastatin A4-Phosphate.- 27. The Heme Oxygenase/Carbon Monoxide System In Hepatobiliary Pathophysiology.- Section V. Heme Oxygenase System and Oxidative Stress Response.- 28. Human Heme Oxygenase (HO)-1 Deficiency and the Oxidative Injury of Vascular Endothelial Cells.- 29. Heme Oxygenase Induction in Liver Cells by Hepatocyte Growth Factor and Oxidative Stress.- 30. Response of Heme Oxygenase and Telomerase Enzymes to Oxidative Stress in Human Hepatoma Cell Line (HepG2).- 31. The Influence of Glucuronidation on In Vitro Assessment of Bilirubin Production as Measure of HO Activity: Studies in Microsomal and Cellular Systems.- 32. Molecular Mechanism of Heme Oxygenase-1 Gene Induction by Activation of the Protein Kinase A-Dependent Signaling Pathway.- 33. Regulation of Heme Oxygenase-1 Gene Transcription Via the Stress-Response Element.- 34. Heme Oxygenase-1: A Major Player in the Defense Against the Oxidative Tissue Injury.- 35. Heme Oxygenase, Ginkgo Biloba Extract and its Terpenoids Protect Myocytes Against Oxidative Injury.- 36. Tobacco-Smoke-Inducible Human Heme Oxygenase-1 Gene Expression: Role of Distinct Transcription Factors and Reactive Oxygen Intermediates.- 37. Doppel Protein Expression Correlates with Heme Oxygenase 1 and Nitric Oxide Synthase Induction.- 38. Generation of Nitric Oxide and Carbon Monoxide Provide Protection Against Cardiac Anaphylaxis.- Section VI. The Network of Heme Oxygenase and Program cell Growth and Death.- 39. Heme Oxygenase-1 Inhibits Vascular Smooth Muscle Cell Proliferation.- 40. Induction of Apoptosis in Vascular Smooth Muscle Cells by Heme Oxygenase-1-Derived Carbon Monoxide.- 41. Role of Heme Oxygenase in Angiogenesis and Renal Carcinoma.- 42. On the Promoting Action of Tamoxifen In the p-Dimethylaminoazobenzene Induced Hepatocarcinogenesis CF1 Mice Model and the Cytoprotective Role of Heme Oxygenase.- 43. Human Heme Oxygenase Gene Transfer Promotes Body Growth and Normalizes Blood Pressure in Spontaneously Hypertensive Rats Without Affecting Sprague-Dawley Rats.