Hematopoietic Stem Cells VIII

Lothar Kanz is a Professor in Hematology, Oncology und Immunology at the University of Tübingen, Tübingen, Germany. Claudia Lengerke, M.D. is Head of the Laboratory for Developmental Biology, Division of Hematology and Oncology, at the University of Tuebingen Medical Center. Willem E. Fibbe is a Professor at Leiden University Medical Center, Leiden, the Netherlands. John E. Dick, PhD is a Senior Scientist in the Division of Cellular & Molecular Biology at Toronto General Research Institute (TGRI), University of Toronto, Toronto, Ontario, Canada.

• Preface for Hematopoietic Stem Cells VIII viiClaudia Lengerke, Willem E. Fibbe, John E. Dick, and Lothar KanzBasic aspects of stem cell biologyEpigenetic differences between sister chromatids? 1Peter M. Lansdorp, Ester Falconer, Jiang Tao, Julie Brind’Amour, and Ulrike NaumannReprogramming cell fates: insights from combinatorial approaches 7Carlos-Filipe Pereira, Ihor R. Lemischka, and Kateri MooreMolecular live cell bioimaging in stem cell research 18Max Endele and Timm SchroederThe role of telomere shortening in somatic stem cells and tissue aging: lessons from telomerase model systems 28Stefan Tümpel and K. Lenhard RudolphHematopoietic stem cell development and molecular regulationIn vivo divisional tracking of hematopoietic stem cells 40Hitoshi Takizawa and Markus G. ManzCaudal genes in blood development and leukemia 47Claudia Lengerke and George Q. DaleyHematopoietic stem cells are regulated by Cripto, as an intermediary of HIF-1α in the hypoxic bone marrow niche 55Kenichi Miharada, Göran Karlsson, Matilda Rehn, Emma Rörby, Kavitha Siva, Jörg Cammenga, and Stefan KarlssonG protein-coupled receptor crosstalk and signaling in hematopoietic stem and progenitor cells 63Robert Möhle and Adriana C. DrostMolecular and functional characterization of early human hematopoiesis 68Elisa Laurenti and John E. DickRole of N-cadherin in the regulation of hematopoietic stem cells in the bone marrow niche 72Fumio Arai, Kentaro Hosokawa, Hirofumi Toyama, Yoshiko Matsumoto, and Toshio SudaDifferential requirements for Wnt and Notch signaling in hematopoietic versus thymic niches 78Paul P.C. Roozen, Martijn H. Brugman, and Frank J.T. StaalPhenotypic and functional heterogeneity of human bone marrow- and amnion-derived MSC subsets 94Kavitha Sivasubramaniyan, Daniela Lehnen, Roshanak Ghazanfari, Malgorzata Sobiesiak, Abhishek Harichandan, Elisabeth Mortha, Neli Petkova, Sabrina Grimm, Flavianna Cerabona, Peter de Zwart, Harald Abele, Wilhelm K. Aicher, Christoph Faul, Lothar Kanz, and Hans-Jörg BühringSafety and efficacy of mesenchymal stromal cell therapy in autoimmune disorders 107Maria Ester Bernardo and Willem E. FibbeStem cells and cancerTIM-3 as a therapeutic target for malignant stem cells in acute myelogenous leukemia 118Yoshikane Kikushige and Koichi AkashiZebrafish xenografts as a tool for in vivo studies on human cancer 124Martina Konantz, Tugce B. Balci, Udo F. Hartwig, Graham Dellaire, Maya C. André, Jason N. Berman, and Claudia LengerkeTranslational researchHematopoietic stem cell expansion: challenges and opportunities 138Marta A. Walasek, Ronald van Os, and Gerald de HaanEnhancing engraftment of cord blood cells via insight into the biology of stem/progenitor cell function 151Hal E. BroxmeyerImmune reconstitution and strategies for rebuilding the immune system after haploidentical stem cell transplantation 161Lena Oevermann, Peter Lang, Tobias Feuchtinger, Michael Schumm, Heiko-Manuel Teltschik, Patrick Schlegel, and Rupert HandgretingerCurrent insights into neutrophil homeostasis 171Stefanie Bugl, Stefan Wirths, Martin R. Müller, Markus P. Radsak, and Hans-Georg KoppProspects and challenges of induced pluripotent stem cells as a source of hematopoietic stem cells 179Dirk W. van Bekkum and Harald M.M. Mikkers