Del i serien Cancer Drug Discovery and Development

Hematopoietic Growth Factors in Oncology

Basic Science and Clinical Therapeutics

Inbunden, Engelska, 2004

AvGeorge Morstyn,MaryAnn Foote,Graham J. Lieschke

2 149 kr

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Leading oncologists, hematologists, and nephrologists comprehensively review the role of HGFs in clinical practice, explain the molecular basis of their effects, and consider potential future developments. The authors focus on the use of HGFs in oncology, describing their cutting-edge application to patients with lung cancer, Hodgkin's and nonhodgkin's lymphoma, breast cancer, chronic lymphocytic leukemia, AIDS-related malignancies, myelodysplastic syndromes, and aplastic anemias. Among the HGFs described are granulocyte colony-stimulating factor, erythropoietc factors, thrombopoietic factors, and stem cell factor and its receptor, C-kit. To complete their survey, the contributors also consider the safety and economic implications of HGFs and the future potential for HGF antagonists in oncology.

Produktinformation

Utgivningsdatum2004-02-05
Mått178 x 254 x undefined mm
FormatInbunden
SpråkEngelska
SerieCancer Drug Discovery and Development
Antal sidor477
FörlagHumana Press Inc.
ISBN9781588293022

Tillhör följande kategorier

Onkologi inom Medicin

I. Basic Research.- 1 Introduction to Hematopoietic Growth Factors: A General Overview.- 2 Animal Models of Hematopoietic Growth Factor Perturbations in Physiology and Pathology.- 3 The Jak/Stat Pathway of Cytokine Signaling.- 4 Small-Molecule and Peptide Agonists: A Literature Review.- II. Hematopoietic Growth Factors.- 5 Granulocyte Colony-Stimulating Factor.- 6 Erythropoietic Factors: Clinical Pharmacology and Pharmacokinetics.- 7 Thrombopoietin Factors.- 8 Stem Cell Factor and Its Receptor, c-Kit.- 9 Hematopoietic Growth Factors: Preclinical Studies of Myeloid and Immune Reconstitution.- III. Use of Hematopoietic Growth Factors in Oncology.- 10 Commentary on the ASCO and ESMO Evidence-Based Clinical Practice Guidelines for the Use of Hematopoietic Colony-Stimulating Factors.- 11 Neutropenia and the Problem of Fever and Infection in Patients With Cancer.- 12 Thrombocytopenia and Platelet Transfusions in Patients With Cancer.- 13 Hematopoietic Growth Factors in Lung Cancer.- 14 Role of Hematopoietic Growth Factors As Adjuncts to the Treatment of Hodgkin’s and Non-Hodgkin’s Lymphomas.- 15 Use of Granulocyte Growth Factors in Breast Cancer.- 16 Role of Cytokines in the Management of Chronic Lymphocytic Leukemia.- 17 Hematopoietic Growth Factor Therapy for Myelodysplastic Syndromes and Aplastic Anemia.- 18 Use of Hematopoietic Growth Factors in AIDS-Related Malignancies.- IV. Safety and Economic Implications.- 19 The Safety of Hematopoietic Growth Factors.- 20 Long-Term Safety of Filgrastim in Chronic Neutropenias.- 21 Economics of Hematopoietic Growth Factors.- V. Future Directions.- 22 Potential for Hematopoietic Growth Factor Antagonists in Oncology.- Acronyms and Selected Abbreviations.