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This volume containing the proceedings of the 13th Yamaguchi Symposium on Liver Disease includes discussion of the direct cellular effects of hepatitis C virus (HCV) proteins on hepatocytes and reviews evidence that oxidative stress caused primarily by the HCV core protein plays a key role in disease pathogenesis.
Alcohol-HCV Interactions in Transgenic Mice Expressing Viral Proteins in the Liver.- Role of Core Protein-Induced Oxidative Stress in the Pathogenesis of Hepatitis C.- Hepatitis C Virus Core-Mediated Alteration of Gene Expression and Signal Transduction in the Host Cell.- Signals Induced by HCV Proteins.- Role of Hepatitis C Virus in Hepatocarcinogenesis: Oxidative Stress in the Absence of Inflammation.- Reduced Chemical Hepatocarcinogenesis in Interferon-? Receptor Knockout Mice.- Fewer Somatic Mutations of Mitochondrial DNA in Noncancerous Liver Tissue Patients with Hepatocellular Carcinoma Respond to Interferon Therapy.- Hepatic Iron Staining in Chronic Hepatitis C Patients with Low HCV RNA Levels as a Predictive Marker for Interferon Therapy.- Hepatic Iron Accumulation and Incidence of Hepatocellular Carcinoma in Patients with Chronic Hepatitis C.- Carbon Monoxide as a Gaseous Regulator of Liver Microcirculation.- Tamoxifen-Induced Nonalcoholic Steatohepatitis.