Edited by Peter Gloviczki MD PhD FACSJoe M. and Ruth Roberts Professor of Surgery and Chair, Emeritus, Division of Vascular and Endovascular Surgery, Director, Emeritus, Gonda Vascular Center, Mayo Clinic, Rochester, Minnesota, USAAssociate Editors: Michael C. Dalsing MD FACSDale and Susan E. Habegger Professor of Surgery and Chair, Emeritus, Division of Vascular Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USAMonika L. Gloviczki MD PhDResearch Fellow, Emeritus, Department of Internal Medicine and Gonda Vascular Center, Mayo Clinic, Rochester, Minnesota, USAFedor Lurie MD PhDAdjunct Research Professor, University of Michigan, Ann Arbor, Michigan, and Associate Director, Jobst Vascular Institute, Toledo, Ohio, USAGregory L. Moneta MD FACSProfessor of Surgery, Division of Vascular Surgery, Oregon Health & Science University. Portland, Oregon, USACynthia K. Shortell MD FACSProfessor of Vascular and Endovascular Surgery, Executive Vice Chair, Department of Surgery, Duke University Medal Center, Durham, North Carolina, USAThomas W. Wakefield MD FACSProfessor Emeritus of Surgery, Section of Vascular Surgery, University of Michigan, Ann Arbor, Michigan, USA

• Part 1. BASIC CONSIDERATIONS OF VENOUS DISORDERS, A historical review of venous and lymphatic disease, Development and anatomy of the venous system, Physiology and hemodynamics of the normal venous circulation, Epidemiology, genetics and risk factors of acute venous thrombosis, Pathogenesis and new insights into acute and chronic venous thrombosis, Epidemiology, genetics and risk factors of chronic venous disease, Pathogenesis and hemodynamics of varicose veins and chronic venous insufficiency of the lower limb, Venous ulcer formation and healing at cellular levels Classification of chronic venous disorders of the lower limbs, Part 2. DIAGNOSTIC EVALUATIONS AND VENOUS IMAGING STUDIES, Evaluation of hypercoagulable states and molecular markers of acute venous thrombosis, Duplex ultrasound scanning for acute venous disease, Duplex ultrasound scanning for chronic venous obstruction and valvular incompetence, Evaluation of venous function by indirect noninvasive testing (plethysmography), Direct contrast venography Intravascular ultrasound (IVUS), Computed tomography and magnetic resonance imaging in venous disease, Part 3. MANAGEMENT OF ACUTE THROMBOSIS, Clinical presentation and the natural history of acute venous thrombosis, Diagnostic algorithms for acute deep venous thrombosis and pulmonary embolism, Medical treatment of acute deep venous thrombosis and pulmonary embolism, Catheter directed thrombolysis for acute iliofemoral deep vein thrombosis Percutaneous mechanical thrombectomy for treatment of acute iliofemoral deep vein thrombosis, Open and hybrid surgical interventions for the treatment of acute iliofemoral deep vein thrombosis Endovascular and open surgical treatment of acute pulmonary embolism, Treatment algorithms for acute venous thromboembolism, Prevention of deep venous thrombosis, Management of venous thoracic outlet syndrome, Acute central venous thrombosis in the setting of central lines, pace-maker wires and dialysis catheters, Indications, techniques, and results of inferior vena cava filters, Superficial thrombophlebitis, Mesenteric vein thrombosis, Part 4. MANAGEMENT OF CHRONIC VENOUS DISORDERS General Considerations, Clinical presentation and assessment of patients with venous disease, Diagnostic algorithm for chronic venous disorders, Compression therapy for chronic venous disorders, Drug treatment for chronic venous disease, B. Superficial and perforating veins, Liquid sclerotherapy for telangiectasia and varicose veins, Percutaneous laser therapy for telangiectasia and varicose veins, Physician generated foam sclerotherapy for ablation of superficial truncal veins and varicose tributaries, Endovenous microfoam sclerotherapy for ablation of superficial truncal veins and varicose tributaries Phlebectomy, Open surgical treatment for superficial truncal incompetence Saphenous preserving surgical interventions:, Radiofrequency treatment of superficial truncal veins, Endovenous laser treatment of superficial truncal veins, Cyanoacrylate glue treatment of incompetent superficial truncal veins Mechanical Occlusion Chemically Assisted (MOCA) ablations and High Intensity Focused Ultrasound (HIFU) for chronic venous disease, The management of incompetent perforating veins Management of thrombotic complications of endovenous ablations, Treatment algorithm for management of varicose veins, Etiology and management of recurrent varicose veins, C. Deep venous disease, Surgical repair of primary and post-thrombotic valvular incompetence, Artificial valves and endovascular techniques for treatment of venous valvular incompetence, Endovascular reconstruction of primary iliac vein obstruction, Endovascular treatment of post-thrombotic iliofemoral venous obstruction, Endovascular reconstruction of iliocaval venous obstructions, Open and hybrid surgical reconstructions for non-malignant obstructions of the iliofemoral veins and the inferior vena cava, Surgical and endovenous treatment of superior vena cava syndrome, D. Venous Leg Ulcers, Local treatment of venous ulcers., Management algorithm for patients with venous ulcers, E. Pelvic venous disorders, Classification and clinical presentation of pelvic venous disorders, Evaluation and treatment of pelvic venous disorders, Management of vulvar, perineal and pelvic origin lower extremity varicosities, The management of Nutcracker syndrome Ana Fuentes, PART 5. SPECIAL VENOUS PROBLEMS, Management of venous trauma: civilian and military injuries, Primary and secondary tumors of the inferior vena cava and iliac veins, Management of arteriovenous malformations, Management of venous malformations, The management of venous aneurysms, Part 6. LYMPHEDEMA, Pathophysiology of lymphedema, Classification and clinical evaluation of patients with lymphedema, Imaging Modalities for Diagnosis and Treatment of Lymphedema, Physical and medical therapy of lymphedema, Principles of surgical treatment of chronic lymphedema, Treatment of chylous disorders, Part 7. CRITICAL ISSUES IN VENOUS AND LYMPHATIC DISEASE, Disparities in management and outcome of venous disease Standards of accredited office-based venous ultrasonography laboratories and vein centers, Coding and reimbursement for venous disease treatment, Outcomes assessment in acute venous disease, Outcomes assessment of treatments for chronic venous disease, Appropriate use criteria for management of lower extremity chronic venous disease Summary of Guidelines of Venous and Lymphatic Disorders of the American Venous Forum,