Handbook of the Biology of Aging

Dr. Nicolas Musi is a tenured Professor of Medicine (Division of Geriatrics and Gerontology and Division of Diabetes) and Director of the Barshop Institute for Longevity and Aging Studies, the San Antonio Claude D. Pepper Older Americans Independence Center, and the San Antonio Geriatric Research, Education and Clinical Center. He is an active educator and research mentor, and supervises clinical and research fellows, residents and graduate students. In this role, he also functions as Director of a T32 Training Grant on the Biology of Aging. Dr. Peter Hornsby obtained a Ph.D. in Cell Biology at the Institute of Cancer Research of the University of London. He has held faculty positions at the University of California SanDiego, the Medical College of Georgia, and Baylor College of Medicine. Currently he is Professor in Department of Physiology and Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center, San Antonio.

• ForewordPrefaceSection I: Basic Mechanisms of Aging: Models and SystemsChapter 1 – Longevity as a Complex Genetic TraitGeorge L. Sutphin and Ron KorstanjeChapter 2 – The mTOR Pathway and AgingKatherine H. Schreiber, Monique N. O’Leary, and Brian K. KennedyChapter 3 – Sirtuins, Healthspan, and Longevity in MammalsWilliam Giblin and David B. LombardChapter 4 – The Hypoxic Response and AgingScott F. Leiser, Hillary A. Miller, and Matt KaeberleinChapter 5 – The Role of Neurosensory Systems in the Modulation of AgingMichael J. Waterson and Scott D. PletcherChapter 6 – The Naked Mole-Rat: A Resilient Rodent Model of Aging, Longevity, and HealthspanKaitlyn N. Lewis and Rochelle BuffensteinChapter 7 – Contributions of Telomere Biology to Human Age-Related DiseaseTing-Lin B. Yang, Shufei Song, and F. Brad JohnsonChapter 8 – Systems Approaches to Understanding AgingLei Hou, Dan Wang, Hao Cheng, Bo Xian, and Jing-Dong J. HanChapter 9 – Integrative Genomics of AgingJoão Pedro de Magalhães and Robi TacutuChapter 10 – NIA Interventions Testing Program: A Collaborative Approach for Investigating Interventions to Promote Healthy AgingNancy L. Nadon, Richard A. Miller, Randy Strong, and David E. HarrisonChapter 11 – Comparative Biology of Aging: Insights from Long-Lived Rodent SpeciesMichael Van Meter, Vera Gorbunova, and Andrei SeluanovSection II: The Pathobiology of Human AgingChapter 12 – Genetics of Human AgingMiook Cho and Yousin SuhChapter 13 – The Aging Arterial WallMingyi Wang, Robert E. Monticone, and Edward G. LakattaChapter 14 – Age-Related Alterations in Neural PlasticityShannon J. Moore and Geoffrey G. MurphyChapter 15 – The Aging Immune System:  Dysregulation, Compensatory Mechanisms, and Prospects for InterventionLudmila Müller and Graham PawelecChapter 16 – Vascular Disease in Hutchinson Gilford Progeria Syndrome and Aging: Common Phenotypes and Potential MechanismsIngrid A. Harten, Michelle Olive, and Thomas N. WightChapter 17 – Cardiac AgingDao-Fu Dai, Ying-Ann Chiao, Robert J. Wessells, Rolf Bodmer, Hazel H. Szeto, and Peter S. RabinovitchChapter 18 – Current Status of Research on Trends in Morbidity, Healthy Life Expectancy, and the Compression of MorbidityEileen M. Cr4immins and Morgan E. LevineChapter 19 – On the Compression of Morbidity: From 1980 to 2015 and BeyondJames F. Fries