Handbook of the Behavioral Neurobiology of Serotonin

Dr. Müller is Professor of Addiction Medicine at the Friedrich-Alexander-University Erlangen-Nuremberg, Germany. He obtained his PhD in Psychology from the University of Düsseldorf. He did PostDocs at the University of Syracuse (USA), University of Düsseldorf, and University of Brasilia (Brazil) before becoming a Senior Lecturer at the Institute of Psychiatry, King’s College London, UK. In 2010 he joined the Friedrich-Alexander-University of Erlangen-Nuremberg, Germany. He serves on several journal editorial boards and guest edited special issues of Behavioral Brain Research and Brain Research Bulletin. Dr. Müller has published more than 120 scientific papers and book chapters. Kathryn A. Cunningham is a pharmacologist and neuroscientist with a focus on advancing the biological understanding of psychiatric disorders and developing effective and safe therapeutics to maximize human function. Her cross-disciplinary, translational research efforts with chemists, cell biologists and clinical scientists are focused on pinpointing the critical roles of two serotonin proteins (5-HT2A and 5-HT2C receptors) in substance use disorder and the discovery of novel medications to extend abstinence. Her research has been funded continuously for 26 years, has led to three patents for new chemical entities and over 150 publications. Her research and educational contributions have been recognized by the American Society for Pharmacology and Experimental Therapeutics-Astellas Award for Translational Pharmacology and the Marian Fischman Memorial Award and the Mentorship Award from the College on Problems of Drug Dependence. Dr. Cunningham is the author of nearly 150 scientific publications and is currently Associate Editor of ACS Chemical Neuroscience and of Nature Neuropsychopharmacology.

• Section 1: Functional anatomy of the serotonergic system1.1 Evolution of serotonin: sunlight to suicide1.2 From B1 to B9: a guide through hindbrain serotonin neurons with additional views from multidimensional characterization1.3 Serotonin System Function, Organization and Feedback1.4 Ultrastructure of the serotonin innervation in mammalian central nervous system1.5 Classification and Signaling Characteristics of 5-HT Receptors: Towards the Concept of 5-HT Receptosomes1.6 Distribution of 5-HT receptors in the central nervous system: An update1.7 The serotonin2B receptor and neurochemical regulation in the brain1.8 Electrochemical Detection of Serotonin Release in Rodents1.9 Molecular neuroimaging of the serotonergic system with Positron Emission TomographySection 2: The neurophysiology of serotonin2.1 Serotonergic control of excitability: from neuron to networks2.2 Structure and function of serotonin GPCR heteromers2.3 Tryptophan hydroxylase and serotonin synthesis regulation2.4 Serotonylation and neuronal function2.5 The effects of serotonin degradation on psychopathology: Role of monoamine oxidase 2.6 Cellular effects of serotonin in the CNS2.7 Serotonin - lipid interactions and their role in behavior2.8 Serotonin – Pain Modulation2.9 Serotonin regulation of striatal function2.10 Serotonergic regulation of hippocampal rhythmical activity2.11 The loudness dependence of auditory evoked potentials as an electrophysiological marker of central serotonergic neurotransmission: implications for clinical psychiatry and psychopharmacotherapySection 3: Serotonin and systemic control 3.1 5-HT neurons and central CO2 chemoreception3.2 Serotonin: a forgotten signal from the bloodSection 4: Serotonin and behavioural control4.1 Serotonin and development4.2 Roles of serotonin in the fetal brain4.3 Serotonin and sensory processing4.4 Serotonin and basal sensory–motor control4.5 Role of the serotonergic system in appetite and ingestion control4.6 Serotonin in eating behavior4.7 Serotonin and the neurobiology of anxious states4.8 Dorsal raphe serotonergic neurons regulate behavior on multiple timescales4.9 The role of central serotonin in impulsivity, compulsivity and decision-making: Comparative studies in experimental animals and humans4.10 The role of serotonin in learning and memory: a rich pallet of experimental studies4.11 The role of serotonin in performance monitoring and cognitive control4.12 Serotonin and 5-HT2B receptors in microglia control of behavior4.13 The serotonin-free brain: behavioural consequences of Tph2 deficiency in animal modelsSection 5: Serotonin in psychiatric disorders5.1 Serotonin in panic and anxiety disorders5.2 Serotonin and aggression – An update5.3 Revisiting the Behavioral Genetics of Serotonin: Relevance to Anxiety and Depression5.4 Serotonin and schizophrenia5.5 Serotonin neurobiology in cocaine use disorder5.6 The role of serotonin in alcohol use and abuse5.7 The role of serotonin in nicotine abuse and addiction5.8 Serotonin and serotonin receptors in hallucinogen action5.9 The serotonergic system in obsessive compulsive disorder5.10 Peripheral and central serotonin in the regulation of glucose metabolism5.11 The role of serotonin in cortical development: implications for Autism Spectrum Disorder5.12 Genetic, epigenetic, and environmental factors in serotonin associated disease conditions5.13 Functional pharmacogenetics of serotonin receptors in psychiatric drug action5.14 Classic psychedelics as therapeutics for psychiatric disordersSection 6: Serotonin in neurological disorders6.1 Serotonin in Parkinson's disease6.2 Serotonin in seizures and epilepsy: a neurodevelopmental perspective6.3 Serotonin and stroke

"In sum, this volume is a comprehensive reference book that is easily accessible and has substantial utility for clinicians and researchers alike.  While not geared to an undergraduate population or to individuals who do not have at least a foundation in biology, psychology, or medicine, this textbook is a handy reference for clinical and research professionals alike.  This volume is a welcome and worthwhile bookshelf addition, particularly for the busy neuropsychologist or researcher.  All in all, this text serves as a reminder of the important role of serotonin in regards to behavior and physiological function, as well as to all of us to “keep calm and carry on.”" --Julie Gretler, Ph.D. Marianne L. McClain, Psy.D.