Dr. Sajal Chakraborti is a Professor at the Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, India. He did postdoctoral research at the Johns Hopkins Medical Institution, New York Medical College, the University of Utah, and the University of Florida. He has over 35 years of teaching and independent research experience in Biochemistry and Cell Biology. He has published over 110 original research papers, 15 review articles, and 12 books.

• ..I. General Aspects .. 1.1. Calpain as a therapeutic target in B-cell lymphoma and other malignant diseases. 1.2 Proteases in cancer: Theoretical insights on the proteases’ evolutionary pathway. 1. 3 Role of extracellular proteases in Glioblastoma . 1. 4 Metalloprotease in colon cancer proliferation and metastasis. 1.5 Role of proteolytic enzymes in colon cancer. 1.6. Tumor associated fibroblast and ADAMS orchestrate tumor microenvironment in hepatocellular carcinoma. 1.7 Unmasking the Protease Paradigm: Exploring the Molecular .Complexity of Proteases in Breast Cancer. 1. 8 Roles of MM7 in cancer. 1.9. The Role of Matrix Metalloproteinases MMP2 and MMP9 in Ovarian Cancer Progression. II. Signal Transduction Mechanisms..2.1. Role of calpains in cancer: an overview .2.2. Dual role of the ADAMTS family in breast cancer. 2.3. PKC isoforms and autophagy in cancer.2.4. Mechanistic insights into the ferroptotic regulation of ubiquitin specific proteases in gastrointestinal tumors.2.5. Serine proteases as critical modulators of the tumor microenvironment..2.6. Protease paradigm in cancer progression: Roles of Caspase-8 and matrix metalloproteinase family in cancer with special reference to head and neck squamous cell carcinoma..2.7. ENTPDs in the tumor microenvironment: A promising context for cancer diagnosis..2.8 Matrix Metalloproteases in Breast Cancer.2.9. Targeting EGFR-driven signaling of MMP-2 secretion for the management of metastatic cancers..: 2.10 Protease in Signal Transduction Mechanism in Cancer: Unraveling the Role of Proteolytic Enzymes in Tumor Progression. 2.11. Sirtuin inhibition modifies matrix metalloproteinases in cancer..2.12. 2.13 The role of matrix metalloproteinase in molecular and cellular aspects of oral squamous cell carcinoma...2.14 The dichotomous role of CHIP in cancer...III. Gene expression, apoptosis and necrosis..3.1 Mechanisms of apoptotic/necrotic cell death-related proteases: Cysteine and serine proteases.3.2. Apoptotic and non-apoptotic roles of caspases..3.3. Role of cysteine proteases and matrix metalloproteases in apoptosis and necrosis in cancer . 3.4. Role of SIRT1 in the regulation of gene expressions in breast cancer. .3.5. Future Vision of Protease Inhibitors in Context of Cocktail and Singular Therapy..3.6. Regulation of cell death by cysteine proteases in breast cancer. 3.7. Ubiquitin Specific Protease 7 (USP7) – Role in human pathologies and potential targeting opportunities in cancer

Dr. Sajal Chakraborti is a Professor at the Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, India. He did postdoctoral research at the Johns Hopkins Medical Institution, New York Medical College, the University of Utah, and the University of Florida. He has over 35 years of teaching and independent research experience in Biochemistry and Cell Biology. He has published over 110 original research papers, 15 review articles, and 12 books.

• ..I. General Aspects .. 1.1. Calpain as a therapeutic target in B-cell lymphoma and other malignant diseases. 1.2 Proteases in cancer: Theoretical insights on the proteases’ evolutionary pathway. 1. 3 Role of extracellular proteases in Glioblastoma . 1. 4 Metalloprotease in colon cancer proliferation and metastasis. 1.5 Role of proteolytic enzymes in colon cancer. 1.6. Tumor associated fibroblast and ADAMS orchestrate tumor microenvironment in hepatocellular carcinoma. 1.7 Unmasking the Protease Paradigm: Exploring the Molecular .Complexity of Proteases in Breast Cancer. 1. 8 Roles of MM7 in cancer. 1.9. The Role of Matrix Metalloproteinases MMP2 and MMP9 in Ovarian Cancer Progression. II. Signal Transduction Mechanisms..2.1. Role of calpains in cancer: an overview .2.2. Dual role of the ADAMTS family in breast cancer. 2.3. PKC isoforms and autophagy in cancer.2.4. Mechanistic insights into the ferroptotic regulation of ubiquitin specific proteases in gastrointestinal tumors.2.5. Serine proteases as critical modulators of the tumor microenvironment..2.6. Protease paradigm in cancer progression: Roles of Caspase-8 and matrix metalloproteinase family in cancer with special reference to head and neck squamous cell carcinoma..2.7. ENTPDs in the tumor microenvironment: A promising context for cancer diagnosis..2.8 Matrix Metalloproteases in Breast Cancer.2.9. Targeting EGFR-driven signaling of MMP-2 secretion for the management of metastatic cancers..: 2.10 Protease in Signal Transduction Mechanism in Cancer: Unraveling the Role of Proteolytic Enzymes in Tumor Progression. 2.11. Sirtuin inhibition modifies matrix metalloproteinases in cancer..2.12. 2.13 The role of matrix metalloproteinase in molecular and cellular aspects of oral squamous cell carcinoma...2.14 The dichotomous role of CHIP in cancer...III. Gene expression, apoptosis and necrosis..3.1 Mechanisms of apoptotic/necrotic cell death-related proteases: Cysteine and serine proteases.3.2. Apoptotic and non-apoptotic roles of caspases..3.3. Role of cysteine proteases and matrix metalloproteases in apoptosis and necrosis in cancer . 3.4. Role of SIRT1 in the regulation of gene expressions in breast cancer. .3.5. Future Vision of Protease Inhibitors in Context of Cocktail and Singular Therapy..3.6. Regulation of cell death by cysteine proteases in breast cancer. 3.7. Ubiquitin Specific Protease 7 (USP7) – Role in human pathologies and potential targeting opportunities in cancer

Dr. Sajal Chakraborti is a Professor at the Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, India. He did postdoctoral research at the Johns Hopkins Medical Institution, New York Medical College, the University of Utah, and the University of Florida. He has over 35 years of teaching and independent research experience in Biochemistry and Cell Biology. He has published over 110 original research papers, 15 review articles, and 12 books.

• ..I. General Aspects .. 1.1. Calpain as a therapeutic target in B-cell lymphoma and other malignant diseases. 1.2 Proteases in cancer: Theoretical insights on the proteases’ evolutionary pathway. 1. 3 Role of extracellular proteases in Glioblastoma . 1. 4 Metalloprotease in colon cancer proliferation and metastasis. 1.5 Role of proteolytic enzymes in colon cancer. 1.6. Tumor associated fibroblast and ADAMS orchestrate tumor microenvironment in hepatocellular carcinoma. 1.7 Unmasking the Protease Paradigm: Exploring the Molecular .Complexity of Proteases in Breast Cancer. 1. 8 Roles of MM7 in cancer. 1.9. The Role of Matrix Metalloproteinases MMP2 and MMP9 in Ovarian Cancer Progression. II. Signal Transduction Mechanisms..2.1. Role of calpains in cancer: an overview .2.2. Dual role of the ADAMTS family in breast cancer. 2.3. PKC isoforms and autophagy in cancer.2.4. Mechanistic insights into the ferroptotic regulation of ubiquitin specific proteases in gastrointestinal tumors.2.5. Serine proteases as critical modulators of the tumor microenvironment..2.6. Protease paradigm in cancer progression: Roles of Caspase-8 and matrix metalloproteinase family in cancer with special reference to head and neck squamous cell carcinoma..2.7. ENTPDs in the tumor microenvironment: A promising context for cancer diagnosis..2.8 Matrix Metalloproteases in Breast Cancer.2.9. Targeting EGFR-driven signaling of MMP-2 secretion for the management of metastatic cancers..: 2.10 Protease in Signal Transduction Mechanism in Cancer: Unraveling the Role of Proteolytic Enzymes in Tumor Progression. 2.11. Sirtuin inhibition modifies matrix metalloproteinases in cancer..2.12. 2.13 The role of matrix metalloproteinase in molecular and cellular aspects of oral squamous cell carcinoma...2.14 The dichotomous role of CHIP in cancer...III. Gene expression, apoptosis and necrosis..3.1 Mechanisms of apoptotic/necrotic cell death-related proteases: Cysteine and serine proteases.3.2. Apoptotic and non-apoptotic roles of caspases..3.3. Role of cysteine proteases and matrix metalloproteases in apoptosis and necrosis in cancer . 3.4. Role of SIRT1 in the regulation of gene expressions in breast cancer. .3.5. Future Vision of Protease Inhibitors in Context of Cocktail and Singular Therapy..3.6. Regulation of cell death by cysteine proteases in breast cancer. 3.7. Ubiquitin Specific Protease 7 (USP7) – Role in human pathologies and potential targeting opportunities in cancer