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Rosario Moratalla, Mario Gustavo Murer - Handbook of Parkinson's Disease Mechanisms, Inbunden

Inbunden, Engelska, 2025

Del 35 i serien Handbook of Behavioral Neuroscience

Handbook of Parkinson's Disease Mechanisms

Av Rosario Moratalla, Mario Gustavo Murer

3079 kr

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Beskrivning

The Handbook of Parkinson’s Disease Mechanisms offers an integrated overview of the fundamental research devoted to understanding its causes and mechanisms, highlighting recent advances and clinical significance.?With a strong focus on cellular and animal model studies, this book also examines the etiology, pathophysiology, epidemiology and underlying symptoms of Parkinson’s disease.

Written with an interdisciplinary approach, this book provides thorough research that will be of interest to researchers, clinicians and graduate students interested in neurodegenerative diseases.



  • Reviews etiology and pathophysiology of Parkinson's disease
  • Integrates clinical and fundamental research
  • Includes cellular, organoid, and animal models of PD
  • Discusses dopamine, neuroinflammation, lysosomal function, tau, Lewy bodies, gut-brain axis, and more
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Rosario Moratalla is a Professor of Neuroscience, Director of the Center of Interdisciplinary Research and Vice-Chair at the Cajal Institute, Consejo Superior de Investigaciones Científicas, Madrid. Dr. Moratalla‘s research interests lie on the dopaminergic system and its role in drug abuse and Parkinson’s disease. She is interested in the molecular mechanisms that modulate cellular responses in the basal ganglia motor circuit, in the context of Parkinson’s disease, L-DOPA-induced dyskinesia and impulse control disorders and drug abuse. In relationship with Parkinson's disease, her studies intend to determine the neurobiological correlates of dyskinesias induced by antiparkinsonian therapy, as well as to establish the neuronal circuits involved in non-motor symptoms of Parkinson’s disease. Gustavo Murer is Professor and Chair of the Institute of Physiology and Biophysics "Bernardo Houssay" at the University of Buenos Aires School of Medicine. Dr. Murer is an expert on the functional alterations that take place in the basal ganglia in Parkinson's disease and other basal ganglia related disorders. His research focuses on the electrophysiological and morphological alterations that take place in the striatum in animal models of Parkinson's disease. His recent investigations examine how chronic dopamine depletion and dopamine replacement therapy produce changes in the activity of basal ganglia neurons, which molecular mechanisms underlie these changes, and how they modify basal ganglia function and behavior.

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