Handbook of Nucleoside Synthesis

HELMUT VORBRUGGEN is Professor of Chemistry at the Free University in Berlin, Germany. CARMEN RUH-POHLENZ is Research Scientist at Schering AG in Berlin, Germany.

• Foreword. Preface. Acknowledgments. Synthesis of Nucleosides. Introduction. Nucleoside Synthesis. Silyl-Hilbert-Johnson Reaction in the Presence of Friedel-Crafts Catalysts. Mechanism of Nucleoside Formation in the Presence of Friedel-Crafts Catalysts. Special Preparations. Miscellaneous Methods. Alternative Nucleoside-Forming Reactions. Experimental Conditions. Experimental Procedures. Tabular Survey. References. Index.

"...an insightful and detailed analysis?provides a valuable resource for the practitioner and a solid foundation for those new to nucleoside synthesis." (Journal of Medicinal Chemistry, Vol. 45, No. 4, 2002) "...contains much more information than one can assemble from a literature search...allows the reader to compare reaction conditions and the outcome of the reaction...the value of the book is considerable increased by the inclusion of experimental details and protocols based on the experience of the authors...highly recommended for everybody interested.... It is expected that this book will become, just like the Vorbruggen reaction itself, a classic in nucleoside chemistry." (Angewandte Chemie International Edition, Vol. 41, No. 9, 2002)"...a comprehensive review of nucleoside synthesis..." (SciTech Book News, Vol. 26, No. 2, June 2002)"...clearly written and well-organized...provides excellent coverage of the contemporary methods used in nucleoside chemistry..." (ChemBioChem, Vol 4(5), 2003)