Handbook of Microcirculation

Ronald F. Tuma is G.H. Stewart Professor of Physiology, Professor of Neurosurgery and Professor in the Center for Substance Abuse Research at the Lewis Katz School of Medicine at Temple University, USA. His research primarily focuses on inflammatory reactions that contribute to central nervous system injuries following stroke, trauma, and autoimmune diseases. He also investigates how modulation of specific cannabinoid receptors can influence the progression of these diseases. Findings from his work has provided valuable insights into potential therapeutic approaches for these conditions. Jerome W. Breslin is Professor of Molecular Pharmacology and the Associate Chair of Education and Faculty Development Physiology at the University of South Florida, USA. His research looks at the effects of edema that occurs after traumatic injury or chronically with long-term diseases. His lab focus on understanding the mechanisms that promote healthy microvascular barrier and lymphatic transport functions at the molecular, cellular, tissue, and whole organism level has resulted in the identification of novel molecular mechanisms that could serve as potential therapeutic targets to prevent or resolve edema associated with traumatic injury, metabolic diseases, or lymphatic diseases. Shayn Peirce-Cottler is Professor and Chair of Biomedical Engineering at the University of Virginia. She is also a Harrison Distinguished Teaching Professor. Her laboratory focuses on engineering microvessels and combines wet lab and machine learning to study tissue healing and develop new therapies for tissue regeneration.  By addressing a critical bottleneck in tissue engineering on how to grow functional and sustainable microvessels, her work has provided significant insights into potential therapeutic approaches for tissue regeneration and microvascular health. Walter Lee Murfee is Professor and Associate Chair for Undergraduate Studies in the J. Crayton Pruitt Family Department of Biomedical Engineering at the University of Florida, USA. His research focuses on microvascular dynamics, including the functional relationship between angiogenesis, lymphangiogenesis, and neurogenesis. Through exploreing how to engineer functional vascularized tissues and studies vascular dysfunction associated with pathological conditions, his work has helped to develop therapies for vascular dysfunctions associated with conditions like hypertension, tumor growth, and wound healing.

• Chapter 1. Blood Flow in Microvascular Networks.- Chapter 2. Microcirculatory Exchange Physiology and Molecular Mechanisms Controlling Microvascular Permeability.- Chapter 3. The Endothelial Glycocalyx in Health and Human Disease.- Chapter 4. Function and Plasticity of Microvascular Pericytes.- Chapter 5. Function and Plasticity of Microvascular Pericytes.- Chapter 6. Physiology and Pathobiology of Microvascular Endothelium.- Chapter 7. The Cerebral Microcirculation.- Chapter 8. Regulation of Coronary Microvascular Resistance in Health and Disease.- Chapter 9. Ocular Circulation.- Chapter 10. Microcirculation in Wound Healing.- Chapter 11. Sickle Cell Anemia.- Chapter 12. Microvascular Effects of Cannabinoids.- Chapter 13. Tumor Microcirculation: Abnormalities and Normalization.- Chapter 14. Microvascular Disfunction Related to COVID-19 and Systemic Inflammation.- Chapter 15. Mural Cells, Microvessels and Alzheimers Disease.- Chapter 16. Imaging Microvascular Morphology and Hemodynamics.- Chapter 17. Biomimetic Models for Investigation of Microvascular Remodeling.