Hans-Joachim Hübschmann, PhD, graduated as Certified Food Chemist from the Technical University in Berlin, Germany. In 2002 he joined Thermo Fisher Scientific in Bremen, Germany, and held different international positions in inorganic and isotope ratio mass spectrometry and high-resolution GC-MS and GC-MS/MS. In 2015 he established the independent consulting agency HANS Analytical Solutions. In his current capacity Hans-Joachim is serving private and industrial laboratories and international analytical instrument companies for green and automated methods development as well as trainings.

• Foreword xviiPreface to the Fourth Edition xix1 Introduction 11.1 The Historical Development of the GC-MS Technique 4References 72 Fundamentals 92.1 Sample Preparation 9References 1052.2 Gas Chromatography 128References 2732.3 Mass Spectrometry 291References 4003 Evaluation of GC-MS Analyses 4133.1 Display of Chromatograms 4133.2 Substance Identification 4183.3 Quantitation 5053.4 Frequently Occurring Impurities 523References 5314 Applications 5414.1 Air Analysis According to U.S. EPA Method TO- 14 5414.2 BTEX in Surface Water as of U.S. EPA Method 8260 5494.3 Volatile Priority Pollutants 5544.4 MAGIC 60 – VOC Analysis 5604.5 irm-GC-MS of Volatile Organic Compounds 5694.6 Organotin Compounds in Water 5724.7 Analysis of Dithiocarbamate Pesticides 5774.8 Pesticides Multi-Method by Single Quadrupole MS 5844.9 QuEChERSER Analysis of Pesticides 5944.10 Pesticide Analysis with Ethyl Acetate Extraction and Automated Micro-SPE Clean-up 5994.11 Multi-Residue Pesticides Analysis in Ayurvedic Churna 6034.12 Polar Aromatic Amines by SPME 6144.13 Phthalates in Liquors 6194.14 Natural Spice Ingredients Capsaicin, Piperine, Thymol, and Cinnamaldehyde 6264.15 Geosmin and Methylisoborneol in Drinking Water 6324.16 Flavor and Fragrance Profiling by Dual-Column GC-MS 6374.17 Aroma Profiling of Cheese 6444.18 Allergens 6494.19 Metabolite Profiling 6564.20 Extractables and Leachables 6654.21 Volatiles in Car Interiors 6774.22 Azo Dyes in Leather and Textiles 6834.23 Fast GC of 16 Priority PAHs 6914.24 Environmental Contaminants in Fish 6974.25 Fast GC of PCBs 7124.26 Dioxin Screening in Food and Feed 7184.27 Confirmation Analysis of Dioxins and Dioxin-like PCBs 730-4.28 U.S. EPA 1614 Brominated Flame Retardants PBDEs 7394.29 PBB Analysis by SPME 7474.30 THC-A in Urine by NCI 7514.31 Comprehensive Drug Screening and Quantitation 7574.32 Drugs of Abuse 7624.33 Structure Elucidation by CI and MS/MS 766References 770Glossary 787Further Reading 858Author Index 859Subject Index 861Compound Index 881

Hans-Joachim Hübschmann, PhD, graduated as Certified Food Chemist from the Technical University in Berlin, Germany. In 2002 he joined Thermo Fisher Scientific in Bremen, Germany, and held different international positions in inorganic and isotope ratio mass spectrometry and high-resolution GC-MS and GC-MS/MS. In 2015 he established the independent consulting agency HANS Analytical Solutions. In his current capacity Hans-Joachim is serving private and industrial laboratories and international analytical instrument companies for green and automated methods development as well as trainings.

• Foreword xviiPreface to the Fourth Edition xix1 Introduction 11.1 The Historical Development of the GC-MS Technique 4References 72 Fundamentals 92.1 Sample Preparation 9References 1052.2 Gas Chromatography 128References 2732.3 Mass Spectrometry 291References 4003 Evaluation of GC-MS Analyses 4133.1 Display of Chromatograms 4133.2 Substance Identification 4183.3 Quantitation 5053.4 Frequently Occurring Impurities 523References 5314 Applications 5414.1 Air Analysis According to U.S. EPA Method TO- 14 5414.2 BTEX in Surface Water as of U.S. EPA Method 8260 5494.3 Volatile Priority Pollutants 5544.4 MAGIC 60 – VOC Analysis 5604.5 irm-GC-MS of Volatile Organic Compounds 5694.6 Organotin Compounds in Water 5724.7 Analysis of Dithiocarbamate Pesticides 5774.8 Pesticides Multi-Method by Single Quadrupole MS 5844.9 QuEChERSER Analysis of Pesticides 5944.10 Pesticide Analysis with Ethyl Acetate Extraction and Automated Micro-SPE Clean-up 5994.11 Multi-Residue Pesticides Analysis in Ayurvedic Churna 6034.12 Polar Aromatic Amines by SPME 6144.13 Phthalates in Liquors 6194.14 Natural Spice Ingredients Capsaicin, Piperine, Thymol, and Cinnamaldehyde 6264.15 Geosmin and Methylisoborneol in Drinking Water 6324.16 Flavor and Fragrance Profiling by Dual-Column GC-MS 6374.17 Aroma Profiling of Cheese 6444.18 Allergens 6494.19 Metabolite Profiling 6564.20 Extractables and Leachables 6654.21 Volatiles in Car Interiors 6774.22 Azo Dyes in Leather and Textiles 6834.23 Fast GC of 16 Priority PAHs 6914.24 Environmental Contaminants in Fish 6974.25 Fast GC of PCBs 7124.26 Dioxin Screening in Food and Feed 7184.27 Confirmation Analysis of Dioxins and Dioxin-like PCBs 730-4.28 U.S. EPA 1614 Brominated Flame Retardants PBDEs 7394.29 PBB Analysis by SPME 7474.30 THC-A in Urine by NCI 7514.31 Comprehensive Drug Screening and Quantitation 7574.32 Drugs of Abuse 7624.33 Structure Elucidation by CI and MS/MS 766References 770Glossary 787Further Reading 858Author Index 859Subject Index 861Compound Index 881

Hans-Joachim Hübschmann, PhD, graduated as Certified Food Chemist from the Technical University in Berlin, Germany. In 2002 he joined Thermo Fisher Scientific in Bremen, Germany, and held different international positions in inorganic and isotope ratio mass spectrometry and high-resolution GC-MS and GC-MS/MS. In 2015 he established the independent consulting agency HANS Analytical Solutions. In his current capacity Hans-Joachim is serving private and industrial laboratories and international analytical instrument companies for green and automated methods development as well as trainings.

• Foreword xviiPreface to the Fourth Edition xix1 Introduction 11.1 The Historical Development of the GC-MS Technique 4References 72 Fundamentals 92.1 Sample Preparation 9References 1052.2 Gas Chromatography 128References 2732.3 Mass Spectrometry 291References 4003 Evaluation of GC-MS Analyses 4133.1 Display of Chromatograms 4133.2 Substance Identification 4183.3 Quantitation 5053.4 Frequently Occurring Impurities 523References 5314 Applications 5414.1 Air Analysis According to U.S. EPA Method TO- 14 5414.2 BTEX in Surface Water as of U.S. EPA Method 8260 5494.3 Volatile Priority Pollutants 5544.4 MAGIC 60 – VOC Analysis 5604.5 irm-GC-MS of Volatile Organic Compounds 5694.6 Organotin Compounds in Water 5724.7 Analysis of Dithiocarbamate Pesticides 5774.8 Pesticides Multi-Method by Single Quadrupole MS 5844.9 QuEChERSER Analysis of Pesticides 5944.10 Pesticide Analysis with Ethyl Acetate Extraction and Automated Micro-SPE Clean-up 5994.11 Multi-Residue Pesticides Analysis in Ayurvedic Churna 6034.12 Polar Aromatic Amines by SPME 6144.13 Phthalates in Liquors 6194.14 Natural Spice Ingredients Capsaicin, Piperine, Thymol, and Cinnamaldehyde 6264.15 Geosmin and Methylisoborneol in Drinking Water 6324.16 Flavor and Fragrance Profiling by Dual-Column GC-MS 6374.17 Aroma Profiling of Cheese 6444.18 Allergens 6494.19 Metabolite Profiling 6564.20 Extractables and Leachables 6654.21 Volatiles in Car Interiors 6774.22 Azo Dyes in Leather and Textiles 6834.23 Fast GC of 16 Priority PAHs 6914.24 Environmental Contaminants in Fish 6974.25 Fast GC of PCBs 7124.26 Dioxin Screening in Food and Feed 7184.27 Confirmation Analysis of Dioxins and Dioxin-like PCBs 730-4.28 U.S. EPA 1614 Brominated Flame Retardants PBDEs 7394.29 PBB Analysis by SPME 7474.30 THC-A in Urine by NCI 7514.31 Comprehensive Drug Screening and Quantitation 7574.32 Drugs of Abuse 7624.33 Structure Elucidation by CI and MS/MS 766References 770Glossary 787Further Reading 858Author Index 859Subject Index 861Compound Index 881