Dr. Tollefsbol is a Distinguished Professor at the University of Alabama at Birmingham. He holds doctorates in molecular biology and osteopathic medicine, trained with National Academy of Science members and has over 200 peer-reviewed publications. Reports highlighting the translatability to the lay public of the discoveries made in his laboratory have appeared in international media representing >50 million readers. Dr. Tollefsbol has been featured as an Investigator in the Spotlight by the NIH as well as a Scientist in the Spotlight by ScienceNow. He is an Associate Editor for Frontiers in Genetics, a contributor to Lewin’s GENES classic textbook and Lead Editor for Elsevier’s Translational Epigenetics Series. Dr. Tollefsbol has been named a “Highly Ranked Scholar” worldwide (ScholarGPS). He has been invited for numerous endowed keynote presentations, his research has been highlighted in eScience News and ScienceDaily and he has published 20 scholarly books on topics related to his research.

• 1. Epigenetics OverviewSECTION I: Molecular Mechanisms of Epigenetics2. Mechanisms of DNA Methylation and Demethylation during Mammalian Development 3. Mechanisms of Histone Modification4. The Epigenetics of Non-coding RNA5. Prions and Prion-like Phenomena in Epigenetic Inheritance6. Higher-order Chromatin Organization in Diseases7. Polycomb-group Proteins and Epigenetic Control of Gene ActivitySECTION II: Methods in Epigenetics8. Methods for Assessing DNA Cytosine Modifications Genome-wide9. Analyses of Genome-wide Histone Modifications in the Mammalian Genome10. Techniques for Genome-wide Expression of Non-coding RNA11. Computational EpigeneticsSECTION III: Model Organisms of Epigenetics12. Epigenetics of Lower Organisms13. Drosophila Epigenetics14. Models of Mouse Epigenetic Inheritance: Classification, Mechanisms, and Experimental Strategies15. Plant EpigenomicsSECTION IV: Factors Influencing Epigenetic Changes16. Dynamic Changes in Epigenetic Modifications During Mammalian Transitions17. Epigenetic Biomarkers18. Transposable elements shaping the epigenome 19. Metabolic Regulation of DNA Methylation in Mammalian Cells20. Dietary and Metabolic Compounds Affecting Covalent Histone Modifications21. Epigenetics, Stem Cells and Cellular Differentiation 22. Regeneration Epigenetics23. Epigenetics of X-chromosome Inactivation24. Epigenetics of Memory Processes25. Transgenerational Epigenetics26. DNA Methylation Clocks in Age-related DiseaseSECTION V: Evolutionary Epigenetics27. Evolution of Epigenetic Mechanisms in Plants28. Evolution of Epigenetic Mechanisms in Animals and Their Role in Speciation    29. Adaptive Evolution and EpigeneticsSECTION VI: Epigenetic Epidemiology30. Epigenetics of Livestock Breeding31. Nutritional Epigenetics and Metabolic Syndrome32. Epigenetics of Drug Addiction33. Environmental Influence of Epigenetics34. The Gut Microbiota Influence on Human Epigenetics, Health and Disease35. Population PharmacoepigenomicsSECTION VII: Epigenetics and Human Disease36. Cancer Epigenetics37. The Role of Epigenetics in Autoimmune Disorders38. Epigenetics of Brain Disorders39. The Epigenetics of Metabolic Diseases40. Imprinting Disorders in HumansSECTION VIII: Epigenetic Therapy41. DNA Demethylating Agents in Clinical Medicine42. Clinical Applications of Histone Deacetylase Inhibitors43. Combination Epigenetic TherapySECTION XI: The Future of Epigenetics44. New Directions for Epigenetic Research: Application of Engineered DNA-binding Molecules to Locus-specific Epigenetic Research

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Dr. Tollefsbol is a Distinguished Professor at the University of Alabama at Birmingham. He holds doctorates in molecular biology and osteopathic medicine, trained with National Academy of Science members and has over 200 peer-reviewed publications. Reports highlighting the translatability to the lay public of the discoveries made in his laboratory have appeared in international media representing >50 million readers. Dr. Tollefsbol has been featured as an Investigator in the Spotlight by the NIH as well as a Scientist in the Spotlight by ScienceNow. He is an Associate Editor for Frontiers in Genetics, a contributor to Lewin’s GENES classic textbook and Lead Editor for Elsevier’s Translational Epigenetics Series. Dr. Tollefsbol has been named a “Highly Ranked Scholar” worldwide (ScholarGPS). He has been invited for numerous endowed keynote presentations, his research has been highlighted in eScience News and ScienceDaily and he has published 20 scholarly books on topics related to his research.

• 1. Epigenetics OverviewSECTION I: Molecular Mechanisms of Epigenetics2. Mechanisms of DNA Methylation and Demethylation during Mammalian Development 3. Mechanisms of Histone Modification4. The Epigenetics of Non-coding RNA5. Prions and Prion-like Phenomena in Epigenetic Inheritance6. Higher-order Chromatin Organization in Diseases7. Polycomb-group Proteins and Epigenetic Control of Gene ActivitySECTION II: Methods in Epigenetics8. Methods for Assessing DNA Cytosine Modifications Genome-wide9. Analyses of Genome-wide Histone Modifications in the Mammalian Genome10. Techniques for Genome-wide Expression of Non-coding RNA11. Computational EpigeneticsSECTION III: Model Organisms of Epigenetics12. Epigenetics of Lower Organisms13. Drosophila Epigenetics14. Models of Mouse Epigenetic Inheritance: Classification, Mechanisms, and Experimental Strategies15. Plant EpigenomicsSECTION IV: Factors Influencing Epigenetic Changes16. Dynamic Changes in Epigenetic Modifications During Mammalian Transitions17. Epigenetic Biomarkers18. Transposable elements shaping the epigenome 19. Metabolic Regulation of DNA Methylation in Mammalian Cells20. Dietary and Metabolic Compounds Affecting Covalent Histone Modifications21. Epigenetics, Stem Cells and Cellular Differentiation 22. Regeneration Epigenetics23. Epigenetics of X-chromosome Inactivation24. Epigenetics of Memory Processes25. Transgenerational Epigenetics26. DNA Methylation Clocks in Age-related DiseaseSECTION V: Evolutionary Epigenetics27. Evolution of Epigenetic Mechanisms in Plants28. Evolution of Epigenetic Mechanisms in Animals and Their Role in Speciation    29. Adaptive Evolution and EpigeneticsSECTION VI: Epigenetic Epidemiology30. Epigenetics of Livestock Breeding31. Nutritional Epigenetics and Metabolic Syndrome32. Epigenetics of Drug Addiction33. Environmental Influence of Epigenetics34. The Gut Microbiota Influence on Human Epigenetics, Health and Disease35. Population PharmacoepigenomicsSECTION VII: Epigenetics and Human Disease36. Cancer Epigenetics37. The Role of Epigenetics in Autoimmune Disorders38. Epigenetics of Brain Disorders39. The Epigenetics of Metabolic Diseases40. Imprinting Disorders in HumansSECTION VIII: Epigenetic Therapy41. DNA Demethylating Agents in Clinical Medicine42. Clinical Applications of Histone Deacetylase Inhibitors43. Combination Epigenetic TherapySECTION XI: The Future of Epigenetics44. New Directions for Epigenetic Research: Application of Engineered DNA-binding Molecules to Locus-specific Epigenetic Research

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Dr. Tollefsbol is a Distinguished Professor at the University of Alabama at Birmingham. He holds doctorates in molecular biology and osteopathic medicine, trained with National Academy of Science members and has over 200 peer-reviewed publications. Reports highlighting the translatability to the lay public of the discoveries made in his laboratory have appeared in international media representing >50 million readers. Dr. Tollefsbol has been featured as an Investigator in the Spotlight by the NIH as well as a Scientist in the Spotlight by ScienceNow. He is an Associate Editor for Frontiers in Genetics, a contributor to Lewin’s GENES classic textbook and Lead Editor for Elsevier’s Translational Epigenetics Series. Dr. Tollefsbol has been named a “Highly Ranked Scholar” worldwide (ScholarGPS). He has been invited for numerous endowed keynote presentations, his research has been highlighted in eScience News and ScienceDaily and he has published 20 scholarly books on topics related to his research.

• 1. Epigenetics OverviewSECTION I: Molecular Mechanisms of Epigenetics2. Mechanisms of DNA Methylation and Demethylation during Mammalian Development 3. Mechanisms of Histone Modification4. The Epigenetics of Non-coding RNA5. Prions and Prion-like Phenomena in Epigenetic Inheritance6. Higher-order Chromatin Organization in Diseases7. Polycomb-group Proteins and Epigenetic Control of Gene ActivitySECTION II: Methods in Epigenetics8. Methods for Assessing DNA Cytosine Modifications Genome-wide9. Analyses of Genome-wide Histone Modifications in the Mammalian Genome10. Techniques for Genome-wide Expression of Non-coding RNA11. Computational EpigeneticsSECTION III: Model Organisms of Epigenetics12. Epigenetics of Lower Organisms13. Drosophila Epigenetics14. Models of Mouse Epigenetic Inheritance: Classification, Mechanisms, and Experimental Strategies15. Plant EpigenomicsSECTION IV: Factors Influencing Epigenetic Changes16. Dynamic Changes in Epigenetic Modifications During Mammalian Transitions17. Epigenetic Biomarkers18. Transposable elements shaping the epigenome 19. Metabolic Regulation of DNA Methylation in Mammalian Cells20. Dietary and Metabolic Compounds Affecting Covalent Histone Modifications21. Epigenetics, Stem Cells and Cellular Differentiation 22. Regeneration Epigenetics23. Epigenetics of X-chromosome Inactivation24. Epigenetics of Memory Processes25. Transgenerational Epigenetics26. DNA Methylation Clocks in Age-related DiseaseSECTION V: Evolutionary Epigenetics27. Evolution of Epigenetic Mechanisms in Plants28. Evolution of Epigenetic Mechanisms in Animals and Their Role in Speciation    29. Adaptive Evolution and EpigeneticsSECTION VI: Epigenetic Epidemiology30. Epigenetics of Livestock Breeding31. Nutritional Epigenetics and Metabolic Syndrome32. Epigenetics of Drug Addiction33. Environmental Influence of Epigenetics34. The Gut Microbiota Influence on Human Epigenetics, Health and Disease35. Population PharmacoepigenomicsSECTION VII: Epigenetics and Human Disease36. Cancer Epigenetics37. The Role of Epigenetics in Autoimmune Disorders38. Epigenetics of Brain Disorders39. The Epigenetics of Metabolic Diseases40. Imprinting Disorders in HumansSECTION VIII: Epigenetic Therapy41. DNA Demethylating Agents in Clinical Medicine42. Clinical Applications of Histone Deacetylase Inhibitors43. Combination Epigenetic TherapySECTION XI: The Future of Epigenetics44. New Directions for Epigenetic Research: Application of Engineered DNA-binding Molecules to Locus-specific Epigenetic Research

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