Handbook of Endocannabinoid Function in the Central Nervous System

Olivier Manzoni is a Research Director at INSERM in Marseille and director of the International Associated Laboratory CannaLab (University of Indiana, Bloomington USA / Aix-Marseille University, France). His research is centered on understanding the molecular basis of synaptic plasticity in normal and pathological conditions, with a focus on the function of the endocannabinoid system and the effects of cannabis during lifetime. Vivana Trezza is an Associate Professor and Group Leader at Roma Tre University. Her research investigates the brain mechanisms underlying functional and dysfunctional socio-emotional behavior, to identify novel pharmacological targets for neuropsychiatric and neurodevelopmental disorders characterized by aberrant socio-emotional processing. A special emphasis in her research is placed on the role of the endocannabinoid system in the regulation of emotions and cognition through development.

• Section I – History of the endocannabinoid system1. An insider view of the discovery of the endocannabinoid research2. The endocannabinoid system: present, future3. Medical chemistry of the eCB systemSection II – Functional anatomy of the endocannabinoid system4. The endocannabinoid signalosome5. Endocannabinoid biosynthesis, degradation, and transport6. Structure and distribution of endocannabinoids’ receptors7. Endocannabinoid in glial cells8. Endocannabinoid in non-neuronal cells of the CNS9. Endocannabinoid – lipid interactions10. Endocannabinoid and mitochondria11. Sexual differences in the endocannabinoid systemSection III – The neurophysiology of the endocannabinoid system12. Cellular effects of endocannabinoid in the CNS13. Endocannabinoids control of excitability: from neuron to networks14. Endocannabinoids control of synaptic transmission: from neuron to networks15. Endocannabinoids – pain modulation16. Endocannabinoids regulation of striatal functions17. Endocannabinoids regulation of hippocampal functions18. Endocannabinoids regulation of the mesolimbic system19. Endocannabinoids regulation of cortical functions20. Endocannabinoids regulation of spino-cerebellar functions21. Peripheral and central endocannabinoids in the regulation of metabolismSection IV – Endocannabinoids in development and lifetime22. Roles of eCB in the fetal brain and early postnatal development23. Roles of eCB in adolescence and sensitive periods24. Roles of eCB in aging25. Epigenetic control of eCB26. Perinatal cannabinoid exposureSection V – Endocannabinoids and behavioral control27. Endocannabinoids and sensory processing28. Endocannabinoids in motor control29. Role of the eCB system in appetite and eating behavior30. Endocannabinoids and the neurobiology of emotional states31. Endocannabinoids and social behavior32. The role of endocannabinoids in impulsivity, compulsivity, and decision-making33. Endocannabinoids in learning and memory34. Endocannabinoids in cognitionSection VI – Endocannabinoids in psychiatric disorders35. Anxiety and depression36. Endocannabinoids and schizophrenia37. Endocannabinoid neurobiology in cannabis use disorder38. The role of endocannabinoids in alcohol use and abuse39. The role of endocannabinoids in psychostimulant addiction40. The role of endocannabinoids in opioid abuse and addiction41. Endocannabinoids in eating disorders42. Endocannabinoids in autism spectrum disorder43. Endocannabinoids in mental disorders44. Endocannabinoids in OCD and Tourette’sSection VII – Endocannabinoids in neurological disorders45. Endocannabinoids in Parkinson's disease and neurodegenerative diseases46. Endocannabinoids in seizures and epilepsy47. Endocannabinoids and stroke48. Endocannabinoids and Alzheimer’s49. Endocannabinoids and multiple sclerosis50. Endocannabinoids and brain cancer