Handbook of Alzheimer's Disease and Other Dementias

Neil W. Kowall graduated with his MD from the University of British Columbia in 1979. He received postgraduate training in Internal Medicine at the Beth Israel Deaconess followed by a Neurology residency at Massachusetts General Hospital. After completion of his clinical training he completed a postdoctoral research fellowship and was appointed Assistant Professor of Neurology at Massachusetts General Hospital and Harvard Medical School . He moved to the Bedford VA Medical Center in 1992 where he is now Director of the New England Geriatrics Research Education and Clinical Center. He is a Professor of Neurology and Pathology at Boston University School of Medicine and directs the NIH-funded Boston University Alzheimer’s Disease Center. His major research interests are human neuroanatomy and neuropathology and animal models of neurodegenerative disease. NIH, VA and private foundations support his research. He has published over 100 original peer-reviewed manuscripts. Dr. Kowall has received various awards, including the following: two Medical Research Council Studentship awards, the Russel Prize in Anatomy, the Hamber Prize in Medicine, the Bristol Medical Prize in Pharmacology, the Merck Scholarship in Medical Therapeutics, the Mead Prize in Pediatrics, the FIRST Award (R29) from National Institute of Neurological Disorders and Stroke, the Moore Award for Best Paper on Clinicopathological Correlation from the American Association of Neuropathologists, two Director's Special Quality Awards/Commendations from the Bedford VAMC, and the Zenith Award from the Alzheimer's Association. Andrew E. Budson (MD from Harvard Medical School) is Associate Professor of Neurology at Boston University's School of Medicine. He is also the Director of Cognitive Neuroscience Research at Boston University's Alzheimer's Center. He is a member of the Cognitive Neuroscience Society and American Academy of Neurology. He is on the editorial boards of several journals such as "Neuropsychology," "Cognitive Neuroscience," and "Neurobiology of Aging." He is a frequent invited speaker on Alzheimer's and cognitive disorders. His research uses the techniques of experimental psychology and cognitive neuroscience to understand how memory breaks down in patients with Alzheimer’s disease.

• Contributors ix Foreword xiiPreface xvPart I Common Dementias 11 Alzheimer’s Disease 3Alan M. Mandell and Robert C. Green2 Vascular Dementia 92Angela L. Jefferson, Amanda M. Gentile, and Ravi Kahlon3 Dementia with Lewy Bodies 131Tamara G. Fong and Daniel Z. Press4 Frontotemporal Dementia 145Adam L. Boxer5 Other Dementias 179Peter MorinPart II Pathogenesis and Disease Mechanisms 1956 Genetic Risk Factors for Dementia 197Paul Hollingworth and Julie Williams7 The Neuropathology of the Dementing Disorders 235Ann C. McKee and Brandon E. Gavett8 Amyloid Beta Peptide and the Amyloid Cascade Hypothesis 262Carmela R. Abraham9 Other Mechanisms of Neurodegeneration 277Marina Boziki, Vassilis Papaliagkas, and Magda Tsolaki10 Rational Therapeutics for Alzheimer’s Disease and Other Dementias 301Neil W. KowallPart III Cognitive and Behavioral Dysfunction 313 11 Memory Dysfunction in Dementia 315Andrew E. Budson12 Language Processing in Dementia 336Jamie Reilly, Joshua Troche, and Murray Grossman13 Executive Functioning 369Robert A. Stern, Stacy L. Andersen, and Brandon E. Gavett14 Emotion and Behavior in Alzheimer’s Disease and Other Dementias 416Christopher I. Wright15 Visuospatial Function in Alzheimer’s Disease and Related Disorders 457Alice Cronin-Golomb16 Sleep and Circadian Rhythms in Dementia 483David G. HarperPart IV Neuroimaging in Dementia 50517 Glimpses of the Living Brain with Alzheimer’s Disease 507Ronald J. Killiany18 Functional MRI in Alzheimer’s Disease and Other Dementias 535Maija Pihlajamäki and Reisa A. Sperling19 Molecular Neuroimaging of the Dementias 557Bradford C. Dickerson20 Using EEG and MEG to Understand Brain Physiology in Alzheimer’s Disease and Related Dementias 575Brandon A. AllyIndex 604

“It is a comprehensive volume of work and would be useful for psychologists, medical students, allied health professionals, psychiatrists and clinicians in the field of research and clinical practice.  The handbook is a credit to the author’s work and to all those who work clinically and research with this burgeoning group of individuals.”  (South West Review, 1 June 2014“I believe this textbook will be useful to a variety of readers from different backgrounds and at different stages of training and experience and I would be very glad to have it in my library.”  (International Psychogeriatrics, 25 July 2013)