Handbook of Alzheimer's Disease and Other Dementias

Dr. Neil W. Kowall is Chief of Neurology and Director of the New England GRECC at the VA Boston Healthcare System; he is also Director of the NIH-funded Boston University Alzheimer's Disease Center, Professor of Neurology and Pathology at Boston University School of Medicine, and Lecturer in Neurology at Harvard Medical School. He has published over 170 papers in peer-reviewed journals including Science, Nature, the Journal of Neuroscience, and the Annals of Neurology.Dr. Andrew E. Budson is the Deputy Chief of Staff and a member of the Geriatric Research Education Clinical Center (GRECC) at the VA Boston Healthcare System. He is also Associate Director for Research at the Boston University Alzheimer's Disease Center, Professor of Neurology at Boston University School of Medicine, and Lecturer in Neurology at Harvard Medical School. He was awarded the 2008 Norman Geschwind Prize in Behavioral Neurology and the 2009 Research Award in Geriatric Neurology, both from the American Academy of Neurology, and has published over 75 papers in peer-reviewed journals including the New England Journal of Medicine, Brain, and Cortex.

• Contributors ixForeword xiiPreface xvPart I Common Dementias 11 Alzheimer’s Disease 3Alan M. Mandell and Robert C. Green2 Vascular Dementia 92Angela L. Jefferson, Amanda M. Gentile, and Ravi Kahlon3 Dementia with Lewy Bodies 131Tamara G. Fong and Daniel Z. Press4 Frontotemporal Dementia 145Adam L. Boxer5 Other Dementias 179Peter MorinPart II Pathogenesis and Disease Mechanisms 1956 Genetic Risk Factors for Dementia 197Paul Hollingworth and Julie Williams7 The Neuropathology of the Dementing Disorders 235Ann C. McKee and Brandon E. Gavett8 Amyloid Beta Peptide and the Amyloid Cascade Hypothesis 262Carmela R. Abraham9 Other Mechanisms of Neurodegeneration 277Marina Boziki, Vassilis Papaliagkas, and Magda Tsolaki10 Rational Therapeutics for Alzheimer’s Disease and Other Dementias 301Neil W. KowallPart III Cognitive and Behavioral Dysfunction 31311 Memory Dysfunction in Dementia 315Andrew E. Budson12 Language Processing in Dementia 336Jamie Reilly, Joshua Troche, and Murray Grossman13 Executive Functioning 369Robert A. Stern, Stacy L. Andersen, and Brandon E. Gavett14 Emotion and Behavior in Alzheimer’s Disease and Other Dementias 416Christopher I. Wright15 Visuospatial Function in Alzheimer’s Disease and Related Disorders 457Alice Cronin-Golomb16 Sleep and Circadian Rhythms in Dementia 483David G. HarperPart IV Neuroimaging in Dementia 50517 Glimpses of the Living Brain with Alzheimer’s Disease 507Ronald J. Killiany18 Functional MRI in Alzheimer’s Disease and Other Dementias 535Maija Pihlajamäki and Reisa A. Sperling19 Molecular Neuroimaging of the Dementias 557Bradford C. Dickerson20 Using EEG and MEG to Understand Brain Physiology in Alzheimer’s Disease and Related Dementias 575Brandon A. AllyIndex 604

“It is a comprehensive volume of work and would be useful for psychologists, medical students, allied health professionals, psychiatrists and clinicians in the field of research and clinical practice.  The handbook is a credit to the author’s work and to all those who work clinically and research with this burgeoning group of individuals.”  (South West Review, 1 June 2014“I believe this textbook will be useful to a variety of readers from different backgrounds and at different stages of training and experience and I would be very glad to have it in my library.”  (International Psychogeriatrics, 25 July 2013)