Atul B. Mehta and A. Victor Hoffbrand are both at the Royal Free and University College School of Medicine, Royal Free Hospital, London

• Preface to the fourth edition 6Preface to the first edition 6Glossary 7Normal values 8About the companion website 9Part 1 Basic physiology and practice1 Haemopoiesis: physiology and pathology 102 Normal blood cells I: red cells 143 Normal blood cells II: granulocytes, monocytes and the reticuloendothelial system 184 Normal blood cells III: lymphocytes 205 Lymph nodes, the lymphatic system and the spleen 236 Clinical assessment 247 Laboratory assessment 26Part 2 Red cell disorders8 General aspects of anaemia 309 Iron I: physiology and deficiency 3310 Iron II: overload and sideroblastic anaemia 3611 Megaloblastic anaemia I: vitamin B 12 (B 12) and folate deficiency – biochemical basis, causes 3812 Megaloblastic anaemia II: clinical features, treatment and other macrocytic anaemias 4013 Haemolytic anaemias I: general 4214 Haemolytic anaemias II: inherited membrane and enzyme defects 4415 Haemolytic anaemias III: acquired 4616 Haemolytic anaemias IV: genetic defects of haemoglobin – thalassaemia 4817 Haemolytic anaemias V: genetic defects of haemoglobin – sickle cell disease 52Part 3 Benign disorders of white cells18 Benign disorders of white cells I: granulocytes, monocytes, macrophages 5419 Benign disorders of white cells II: lymphocytes, lymph nodes, spleen, HIV 56Part 4 Haematological malignancies20 Introduction to Haematological malignancy: basic mechanisms 5821 General aspects of treatment 6122 Acute leukaemia I: classification and diagnosis 6423 Acute leukaemia II: treatment and prognosis 6824 Chronic Myeloid Leukaemia (BCR-ABL1 positive) 7025 Myelodysplasia (myelodysplastic syndromes) 7226 Myeloproliferative disorders I: introduction 7427 Myeloproliferative disorders II: polycythaemia rubra vera 7628 Myeloproliferative disorders III: essential thrombocythaemia, primary myelofibrosis and systemic mastocytosis 7829 Chronic lymphocytic leukaemia 8030 Multiple myeloma and plasma cell disorders 8331 Lymphoma I: introduction 8632 Lymphoma II: Hodgkin lymphoma 8833 Lymphoma III: non-Hodgkin lymphoma – aetiology and classification 9034 Lymphoma IV: clinical and laboratory features of more common subtypes 9235 Lymphoma V: treatment and prognosis 94Part 5 Treatment and procedures36 Bone marrow failure 9637 Haematological effects of drugs 9838 Stem cell transplantation 100Part 6 Haemostasis39 Normal haemostasis I: vessel wall and platelets 10240 Normal haemostasis II: coagulation factors and fibrinolysis 10441 Disorders of haemostasis I: vessel wall and platelets 10642 Disorders of haemostasis II: inherited disorders of coagulation 10843 Disorders of haemostasis III: acquired disorders of coagulation 11044 Thrombosis and anti-thrombotic therapy 11245 Anticoagulation 115Part 7 Haematological aspects of tropical disease46 Haematological aspects of tropical diseases 11847 Haematology of pregnancy and infancy 120Part 8 Blood transfusion48 Blood transfusion I 12249 Blood transfusion II 124Appendix: cluster of differentiation nomenclature system 127Index 129

“This book is an invaluable resource for medical students and health professionals wanting to consolidate and expand their knowledge of haematology.”  (Kingbook73's Medical Ebook and Video Collection, 26 August 2014)

Atul B. Mehta and A. Victor Hoffbrand are both at the Royal Free and University College School of Medicine, Royal Free Hospital, London

• Preface to the fourth edition 6Preface to the first edition 6Glossary 7Normal values 8About the companion website 9Part 1 Basic physiology and practice1 Haemopoiesis: physiology and pathology 102 Normal blood cells I: red cells 143 Normal blood cells II: granulocytes, monocytes and the reticuloendothelial system 184 Normal blood cells III: lymphocytes 205 Lymph nodes, the lymphatic system and the spleen 236 Clinical assessment 247 Laboratory assessment 26Part 2 Red cell disorders8 General aspects of anaemia 309 Iron I: physiology and deficiency 3310 Iron II: overload and sideroblastic anaemia 3611 Megaloblastic anaemia I: vitamin B 12 (B 12) and folate deficiency – biochemical basis, causes 3812 Megaloblastic anaemia II: clinical features, treatment and other macrocytic anaemias 4013 Haemolytic anaemias I: general 4214 Haemolytic anaemias II: inherited membrane and enzyme defects 4415 Haemolytic anaemias III: acquired 4616 Haemolytic anaemias IV: genetic defects of haemoglobin – thalassaemia 4817 Haemolytic anaemias V: genetic defects of haemoglobin – sickle cell disease 52Part 3 Benign disorders of white cells18 Benign disorders of white cells I: granulocytes, monocytes, macrophages 5419 Benign disorders of white cells II: lymphocytes, lymph nodes, spleen, HIV 56Part 4 Haematological malignancies20 Introduction to Haematological malignancy: basic mechanisms 5821 General aspects of treatment 6122 Acute leukaemia I: classification and diagnosis 6423 Acute leukaemia II: treatment and prognosis 6824 Chronic Myeloid Leukaemia (BCR-ABL1 positive) 7025 Myelodysplasia (myelodysplastic syndromes) 7226 Myeloproliferative disorders I: introduction 7427 Myeloproliferative disorders II: polycythaemia rubra vera 7628 Myeloproliferative disorders III: essential thrombocythaemia, primary myelofibrosis and systemic mastocytosis 7829 Chronic lymphocytic leukaemia 8030 Multiple myeloma and plasma cell disorders 8331 Lymphoma I: introduction 8632 Lymphoma II: Hodgkin lymphoma 8833 Lymphoma III: non-Hodgkin lymphoma – aetiology and classification 9034 Lymphoma IV: clinical and laboratory features of more common subtypes 9235 Lymphoma V: treatment and prognosis 94Part 5 Treatment and procedures36 Bone marrow failure 9637 Haematological effects of drugs 9838 Stem cell transplantation 100Part 6 Haemostasis39 Normal haemostasis I: vessel wall and platelets 10240 Normal haemostasis II: coagulation factors and fibrinolysis 10441 Disorders of haemostasis I: vessel wall and platelets 10642 Disorders of haemostasis II: inherited disorders of coagulation 10843 Disorders of haemostasis III: acquired disorders of coagulation 11044 Thrombosis and anti-thrombotic therapy 11245 Anticoagulation 115Part 7 Haematological aspects of tropical disease46 Haematological aspects of tropical diseases 11847 Haematology of pregnancy and infancy 120Part 8 Blood transfusion48 Blood transfusion I 12249 Blood transfusion II 124Appendix: cluster of differentiation nomenclature system 127Index 129

“This book is an invaluable resource for medical students and health professionals wanting to consolidate and expand their knowledge of haematology.”  (Kingbook73's Medical Ebook and Video Collection, 26 August 2014)

Atul B. Mehta and A. Victor Hoffbrand are both at the Royal Free and University College School of Medicine, Royal Free Hospital, London

• Preface to the fourth edition 6Preface to the first edition 6Glossary 7Normal values 8About the companion website 9Part 1 Basic physiology and practice1 Haemopoiesis: physiology and pathology 102 Normal blood cells I: red cells 143 Normal blood cells II: granulocytes, monocytes and the reticuloendothelial system 184 Normal blood cells III: lymphocytes 205 Lymph nodes, the lymphatic system and the spleen 236 Clinical assessment 247 Laboratory assessment 26Part 2 Red cell disorders8 General aspects of anaemia 309 Iron I: physiology and deficiency 3310 Iron II: overload and sideroblastic anaemia 3611 Megaloblastic anaemia I: vitamin B 12 (B 12) and folate deficiency – biochemical basis, causes 3812 Megaloblastic anaemia II: clinical features, treatment and other macrocytic anaemias 4013 Haemolytic anaemias I: general 4214 Haemolytic anaemias II: inherited membrane and enzyme defects 4415 Haemolytic anaemias III: acquired 4616 Haemolytic anaemias IV: genetic defects of haemoglobin – thalassaemia 4817 Haemolytic anaemias V: genetic defects of haemoglobin – sickle cell disease 52Part 3 Benign disorders of white cells18 Benign disorders of white cells I: granulocytes, monocytes, macrophages 5419 Benign disorders of white cells II: lymphocytes, lymph nodes, spleen, HIV 56Part 4 Haematological malignancies20 Introduction to Haematological malignancy: basic mechanisms 5821 General aspects of treatment 6122 Acute leukaemia I: classification and diagnosis 6423 Acute leukaemia II: treatment and prognosis 6824 Chronic Myeloid Leukaemia (BCR-ABL1 positive) 7025 Myelodysplasia (myelodysplastic syndromes) 7226 Myeloproliferative disorders I: introduction 7427 Myeloproliferative disorders II: polycythaemia rubra vera 7628 Myeloproliferative disorders III: essential thrombocythaemia, primary myelofibrosis and systemic mastocytosis 7829 Chronic lymphocytic leukaemia 8030 Multiple myeloma and plasma cell disorders 8331 Lymphoma I: introduction 8632 Lymphoma II: Hodgkin lymphoma 8833 Lymphoma III: non-Hodgkin lymphoma – aetiology and classification 9034 Lymphoma IV: clinical and laboratory features of more common subtypes 9235 Lymphoma V: treatment and prognosis 94Part 5 Treatment and procedures36 Bone marrow failure 9637 Haematological effects of drugs 9838 Stem cell transplantation 100Part 6 Haemostasis39 Normal haemostasis I: vessel wall and platelets 10240 Normal haemostasis II: coagulation factors and fibrinolysis 10441 Disorders of haemostasis I: vessel wall and platelets 10642 Disorders of haemostasis II: inherited disorders of coagulation 10843 Disorders of haemostasis III: acquired disorders of coagulation 11044 Thrombosis and anti-thrombotic therapy 11245 Anticoagulation 115Part 7 Haematological aspects of tropical disease46 Haematological aspects of tropical diseases 11847 Haematology of pregnancy and infancy 120Part 8 Blood transfusion48 Blood transfusion I 12249 Blood transfusion II 124Appendix: cluster of differentiation nomenclature system 127Index 129

“This book is an invaluable resource for medical students and health professionals wanting to consolidate and expand their knowledge of haematology.”  (Kingbook73's Medical Ebook and Video Collection, 26 August 2014)