Growth Control During Cell Aging

Eugenia Wang and Huber R. Warner

• INTRODUCTION. POSITIVE CONTROL of CELL PROLIFERATION. The Regulation of Cell Senescence. Expression of Growth-Related Genes in Senescent Human Diploid Fibroblasts. Changes in Gene Expression during Senescence/Immortalization of Mouse Embryo Fibroblasts. Nuclear Responsiveness to Intracellular Signals in Normal and Senescent Lymphocytes. Activation Defects in T Cells from Old Mice. Age-Re-lated Differences in DNA Polymerase Alpha Specific Activity: Potential for Interaction in DNA Repair. Characterization of Proliferating Cell Nuclear Antigen (PCNA), or Cyclin, as a Cellular Marker for S-Phase Cells.. NEGATIVE CONTROL of CELL PROLIFERATION. Cellular Senescence: The Result of a Genetic Program. Inhibitors of DNA Synthesis in Senescent and Quiescent Human Diploid Fibroblasts. Growth Control in Cultured 3T3 Fibroblasts: Molecular Properties of a Growth Regulatory Factor Isolated from Conditioned Medium. Programmed Gene Expressions Suggest Multiple Blocks to Replication during Cell Aging. GENERAL RELATED SUBJECTS. A Potential Role for Interspersed Repetitive Sequence Elements in Negative Growth Regulation. DNA Methylation, Maintenance CpG-Methylase, and Senescence. Finite Proliferative Capacity of Syrian Hamster Fetal and Adult Fibroblasts In Vitro: A Model System for the Analysis of the Cellular Basis of Aging. Cellular Factors Related to Cessation of Proliferation and Differentiation. Control of Muscle Differentiation by Mitogen: A Rationale for Multiple Restriction Points in the Cell Cycle. SUMMARY. Index.