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This detailed book highlights several emerging areas in the implementation of green chemistry in medicinal chemistry drug discovery with a specific focus on their application to the expeditious discovery of new biologically active entities.
Green Synthesis of Common Heterocycles.- Greener Methods for Amide Bond Synthesis.- Mitsunobu Reactions in Medicinal Chemistry and Development of Practical Modifications.- Direct Nucleophilic Substitution of Alcohols by Brønsted or Lewis Acids Activation: An Update.- Friedel-Crafts Reactions.- Ionic Liquids: Design and Applications.- Designing Efficient Cascade Reactions in Drug Discovery.- Multicomponent Synthesis: Cohesive Integration of Green Chemistry Principles.- Direct C–H Functionalization Approaches to Pharmaceutically Relevant Molecules.- C–H Activation with Photoredox Catalysis.- In Situ Protecting Groups for Chemoselective Transformations.- Expanding the Biocatalysis Toolbox.- New Directions in Coupling Chemistry.- Flow Chemistry as an Enabling Technology for Synthetic Organic Chemistry.- Reaction Optimization: A High-Throughput Experimentation Approach.- Radiopharmaceutical Discovery with 11CO2-Fixation Methods Inspired by Green Chemistry.
